Elodie Ghedin, a biomedical researcher at the University of Pittsburgh in Pennsylvania, who uses genomic sequencing techniques to generate insights
into human pathogens.
It should prompt donors and international organizations to ramp up their funding of efforts to control outbreaks of the H5N1 virus in poultry, and so give the virus fewer opportunities to evolve
into a human pathogen, she says.
Not exact matches
Yet it never evolved
into a
pathogen that moved as efficiently as
human flu.
As people move
into formerly wild areas, local
pathogens increasingly come
into contact with new domesticated animal hosts — freshly arrived pigs, chickens, horses — and, eventually,
humans.
But now we need to know the proclivity of a virus or other
pathogen to get
into the
human population.
«As
humans encroach ever more steadily
into natural ecosystems, the risk increases that
pathogens will be transmitted from
humans to animals, or vice versa,» Pallen concluded.
Critics have long argued that transplanting animal tissue
into even a small number of immune - suppressed patients could allow obscure
pathogens to jump from animals to
humans.
Globalisation has resulted in the movement of
humans and animals all across the world, bringing
pathogens into contact with hosts that haven't had the opportunity to establish resistance.
«The role of inappropriate
human action in the spread of
pathogens and the resulting high numbers of colony losses needs to be brought
into the fore of management and policy decisions if we are to reduce colony losses to acceptable levels.»
Since 1996, major changes in infectious diseases have occurred, such as the introduction of
human immunodeficiency virus (HIV) / AIDS and West Nile virus
into the United States, advances in HIV / AIDS treatment, changes in vaccine perceptions, and increased concern over drug - resistant
pathogens.
But INB found a way to trick spinach (along with Swiss chard and petunias)
into producing harmless bits and pieces of common
human pathogens that cause diseases like flu and plague (inset).
Hahn's lab studies ape relatives of
human pathogens such as HIV and malaria to gain a greater insight
into the microbes that cause these diseases in
humans.
Writing in the journal PLoS
Pathogens, the team led by Professor Sachdev Sidhu, of the Donnelly Centre for Cellular and Biomolecular Research and Department of Molecular Genetics, describe how they turned ubiquitin, a staple protein in every cell,
into a drug capable of thwarting MERS in cultured
human cells.
While the manufacturer of Quorn ™ cultivates strains of Fusarium venenatum via fermentation
into a mycoprotein dough for
human consumption, farmers try to fight off Fusarium graminearum as this pervasive fungal
pathogen invades multiple crops and threatens global food security.
Scientists» initial idea was to introduce genes conferring resistance to
human pathogens into mosquitoes, and then enlist Wolbachia to help these traits race through the population.
And the math is simple: More points of contact facilitate more spillovers, and more transmission of animal
pathogens into the
human population.
The pattern of associations his team discovered suggests that today's population retains Neandertal DNA that may have provided modern
humans with adaptive advantages 40,000 years ago — as they migrated
into new non-African environments with different
pathogens and levels of sun exposure.
Analysis of the genome provides new insights
into the workings and genome evolution of a major
human pathogen.
In infants, it's probably a feature rather than a flaw:
human milk oligosaccharides, normally valued only for their prebiotic qualities, get
into the bloodstream to mop up and clear
pathogens while the immune system is still in its, ahem, infancy.
When consumed by
humans, saponins can create holes in the gut wall, increasing leaky gut and allowing
pathogens and toxins
into the bloodstream.
There has been little study of the possibility that gut
pathogens will incorporate Neu5Gc from food
into their cell walls, potentially triggering autoimmunity against Neu5Gc incorporated in
human cells.
To date, the published research on this topic has focused on the possibility of
pathogens incorporating Neu5Ac, the primary
human sialic acid, from
human cells
into their cell walls, and subsequently triggering autoimmunity against Neu5Ac.
So to generate autoimmunity against Neu5gc incorporated in
human cells, B cells must first be triggered to form high - affinity anti-Neu5gc antibodies by meeting bacterial
pathogens who have incorporated Neu5gc
into their cell walls.
The disease occurs when ticks infected by the Lyme Disease bacterium bite a pet (or a
human) and transmit the
pathogen into the body.
This strain is considered a
pathogen in
human medicine (many production companies will not bring this strain
into their facilities), but is one of the more effective strains used for dogs and cats.
Other aspects of global warming's broad footprint on the world's ecosystems include changes in the abundance of more than 80 percent of the thousands of species included in population studies; major poleward shifts in living ranges as warm regions become hot, and cold regions become warmer; major increases (in the south) and decreases (in the north) of the abundance of plankton, which forms the critical base of the ocean's food chain; the transformation of previously innocuous insect species like the Aspen leaf miner
into pests that have damaged millions of acres of forest; and an increase in the range and abundance of
human pathogens like the cholera - causing bacteria Vibrio, the mosquito - borne dengue virus, and the ticks that carry Lyme disease - causing bacteria.
For example, stormwater across the city of Milwaukee recently showed high
human fecal
pathogen levels at all 45 outflow locations, indicating widespread sewage contamination.87 One study estimated that increased storm events will lead to an increase of up to 120 % in combined sewer overflows
into Lake Michigan by 2100 under a very high emissions scenario (A1FI), 57 leading to additional
human health issues and beach closures.