In flu surveillance, researchers look primarily for the genes encoding the virus's surface proteins, hemagglutinin and neuraminidase; if they sequence the so - called internal genes as well, they might detect new genes slipping
into human virus strains in the run - up to a pandemic, they say.
Not exact matches
Trojans are typically spread by social engineering - for example, by tricking people
into clicking a link, installing an app, or running some email attachment - and, as such, unlike
viruses and worms, Trojans typically do not self - propagate - instead, they rely on
human involvement.
This is quite similar to the way the
human body develops antibodies to fight
viruses and provide ongoing immunity when a person comes
into contact with a transient illness.
The team found that when LANA is cloned
into a
virus similar to Kaposi, but which infects mice instead of
humans, it preserves its functionality.
To find out, the biologists developed a way to incorporate the gene for the
human L - type photopigment
into a small
virus known as adeno - associated
virus.
A
human antibody specific for dengue
virus locks viral envelope proteins
into a conformation that prohibits viral entry.
A crowded stall in Guangdong is where the
virus that causes severe acute respiratory syndrome (SARS) jumped from an animal, probably a civet cat,
into a
human in 2003.
The vaccine consists of
human viral proteins inserted
into a similar
virus affecting rhesus monkeys.
Once inside a host animal the two
viruses swapped genetic material, resulting in a new form of SIV that eventually crossed
into humans.
Yet a novel strain of the influenza A (H1N1)
virus jumped species and burst
into the
human population in March and April, and by late May health and agriculture officials were still trying to figure out where it came from.
It is caused by an H1N1
virus which evolves directly from a bird flu
into a
human flu.
A panel of small molecules that inhibit Zika
virus infection, including one that stands out as a potent inhibitor of Zika viral entry
into relevant
human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.
African green monkeys carry a type of SIV, but it is too unlike HIV genetically to have evolved
into HIV between 1957 and the first undisputed appearance of the
human virus in Africa.
This new vaccine employs a
virus not harmful to
humans called vesicular stomatitis
virus that had a part of the Ebola
virus inserted
into it.
Shah and his team loaded the herpes
virus into human MSCs and injected the cells
into glioblastoma tumors developed in mice.
But if you put that same
virus into a rhesus macaque, the monkey's immune system reacts similarly to that of
humans; there is severe depletion of CD4 T cells and progression to AIDS, explains U.C.S.F. researcher Peter Hunt.
In this technique, the DNA of the
human virus is not incorporated
into the plant's genes, so it isn't present in the seeds or pollen.
The
virus is not currently capable of spreading sustainably from
human to
human, but scientists are concerned that it could potentially mutate
into a form that can.
Researchers injected both the naked
virus and SEVI - treated HIV
into the tails of rats that had been given
human immune system cells.
Although the
viruses are found most often in Africa, they have been unintentionally imported
into the United States and Europe several times, and in recent years a version of the Ebola
virus has been found replicating in swine raised for
human consumption in Asia.
But now we need to know the proclivity of a
virus or other pathogen to get
into the
human population.
Understanding what combination of mutations could transform H5N1
into a
human pandemic
virus gives epidemiologists a leg up on preparing countermeasures; they can, for example, test existing vaccines against the new strain.
It should prompt donors and international organizations to ramp up their funding of efforts to control outbreaks of the H5N1
virus in poultry, and so give the
virus fewer opportunities to evolve
into a
human pathogen, she says.
The process enables some
viruses to insert their genetic material
into the DNA of healthy
human cells, which can lead to tumors and other diseases.
Scientists have now discovered that these
viruses have integrated themselves
into the DNA of a wide range of animals, including
humans, zebrafish, and other vertebrates.
Flu
viruses involved in
human epidemics are divided
into types A and B, and A
viruses are sliced even further
into group 1 and group 2.
The stem cells, derived from
human umbilical cord - blood and coaxed
into an embryonic - like state, were grown without the conventional use of
viruses, which can mutate genes and initiate cancers, according to the scientists.
HeLa allowed researchers to study polio, measles, papilloma
virus (HPV), HIV and tuberculosis; it was used to create the first
human - mouse cell hybrid, and even sent
into space.
In less than 1 percent of all adults, the
virus can also quietly slip its own DNA
into the
human genome — making it possible for mothers and fathers to pass HHV - 6 to their offspring if these insertions are present in their eggs or sperm.
Neuroscientist Steven Jacobson and his colleagues at the National Institute of Neurological Disorders and Stroke have determined that the
virus makes its entry to the
human brain through the olfactory pathway, right along with the odors wafting
into our nose.
They believe a vaccine that stimulates the body to produce more of these cells could be effective at preventing flu
viruses, including new strains that cross
into humans from birds and pigs, from causing serious disease.
Researchers estimate that one of every 116 newborns may have
human herpesvirus 6 (HHV - 6) infections that originated when the
virus inserted its genetic material
into that of their parents» DNA.
The research does not conclude that the Asian tiger mosquito (Aedes albopictus) can transmit Zika to
humans, but it highlights the need for deeper research
into additional potential vectors for the
virus that has rapidly spread through the Americas since its initial outbreak in 2015, says Chelsea Smartt, Ph.D., associate professor at the Florida Medical Entomology Laboratory at the University of Florida and lead author on the study to be published this week in the Entomological Society of America's Journal of Medical Entomology.
Understanding where our
viruses come from will help guide us in preventing future
viruses from making the jump
into humans.»
«The results help us to better understand how these
viruses evolved and found their way
into humans,» said Joel O. Wertheim, PhD, assistant research scientist at the UC San Diego AntiViral Research Center and lead author of the study.
B: Well, we were in the midst of experiments aiming to use an animal
virus to introduce new genes
into human cells and
into bacterial cells.
One of the lessons was that there may be a fair amount of cross-protective immunity in the
human population to a number of the
viruses currently circulating in swine, some of which were introduced
into pigs from people in the past.
JUDY MIKOVITS HAD BEEN SO COCOONED IN the world of AIDS that she had never heard of chronic fatigue syndrome until 2006, when she was hired to consult for a Santa Barbara — based foundation supporting investigation
into human herpes
virus six (HHV6), which had been implicated in the disease.
Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted healthy
human ADA genes
into a modified mouse retrovirus — a type of
virus that can enter
human cells and transfer new genetic material right
into the DNA strands in their nuclei.
Comparing results in monkeys and
humans, the
viruses approximately clustered
into the four known groups.
After that was settled, gene therapists still had to find a suitable
virus, or vector, to carry replacement genes
into human cells without inciting a damaging or deadly immune response.
Greber and his team infected
human cells in culture with the chemically labeled
viruses, and observed the behavior of the viral DNA during entry
into cells.
Just as flu season swings
into full gear, researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the
human immune system tries to battle the influenza A
virus.
The new study shows that the synthetic compound is capable of inhibiting the activities of several DNA - processing enzymes, including the «integrase» used by the
Human Immunodeficiency
Virus (HIV) to insert its genome
into that of its host cell.
When they delivered this
virus into the noses of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range of dangerous influenza
viruses that no single vaccine can outwit, including H5N1, which kills both birds and
humans, and the H1N1 that caused the infamous 1918 pandemic.
T - VEC, also called talimogene laherparepvec, is a
human herpes simplex
virus that is genetically engineered to bring T cells
into a tumor and induce an antitumor response.
Proliferation of such scavengers could bring bacteria and
viruses from carcasses
into human cities.
Taking advantage of this, researchers can insert therapeutic genes
into a
virus, then use the
viruses to shuttle the genes to the appropriate cells or tissues inside a
human body.
Most gene - therapy trials use
viruses to deliver genes to a patient's cells, and most of those
viruses are retroviruses, which have the ability to neatly splice their genes — and the
human gene they're carrying —
into a cell's chromosomes.
Zika
virus «spillback»
into primates raises risk of future
human outbreaks.