Sentences with phrase «into immunodeficient mice»

When injected into immunodeficient mice, the iPS cells grew into neural tissue, cartilage, muscle, and forebears of cells that line the intestinal tract — representing all classes of tissue that give rise to a complete body.

Moreover, the iPS cells can spontaneously differentiate or be induced into various cell types of three embryonic germ layers in vitro and in vivo when they are injected into immunodeficient mice for teratoma formation.

Upon orthotopic transplantation into immunodeficient mice, these organoids form normal pancreatic ducts and acinar tissue resembling fetal human pancreas without evidence of tumour formation or transformation.

They developed a simple system that allows them to transplant human hepatocytes into immunodeficient mice, which can now be used to test how drugs affect the liver.

«They displayed all the characteristics of cancer stem cells, and less than 100 and as few as 10 cells were enough to initiate a tumor when injected into immunodeficient mice,» says Friedmann - Morvinski.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Patient - derived xenographs involve the implantation of tumor tissue into an immunodeficient mouse which becomes an avatar to help identify which drug or drug combinations are most likely to be effective for an individual cancer patient.

Not exact matches

The research team found that injection of CAR T cells into 79 immunodeficient mice arrested the growth of GBM in 60 % of them.

There was scant experimental evidence for this hypothesis until 1994, when John Dick and colleagues demonstrated that leukemia - initiating stem cells (LSCs) present in the blood of leukemia patients may induce acute myelogenous leukemia (AML) when transplanted into severe combined immunodeficient mice (2).

To directly examine whether ABL kinases play a role in regulating the colonization and survival of breast cancer cells in the bone microenvironment, we injected control or ABL1 / ABL2 knockdown breast cancer cells directly into the tibia of immunodeficient mice.

When infused into mice bearing human tumors, CD26high T cells more efficiently reconstituted immunodeficient hosts and persisted long - term compared to other subsets.

Using the highly immunodeficient NSG ™ mice [NOD.Cg - Prkdcscid Il2rgtm1Wjl / SzJ (005557)-RSB- as a host, they injected hu - PBMCs directly into the spleen along with HIV engineered to express luciferase (HIV - LucR).

Humanized mouse models, where human tumor tissue is engrafted into immunodeficient NOD SCID gamma (NSG) mice, are frequently used in oncology and infectious disease studies to provide valuable translational insights.