Sentences with phrase «into key pathways»

«Intuitively, one might expect disease - causing variants to cluster into key pathways that drive disease etiology [the causes of disease],» they write.

Not exact matches

Stomach switch The key to turning pluripotent stem cells into stomach cells was a pathway of interactions that acts as a switch between growing tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.

Understanding what happens with the UPR in disease is key to illuminating the normal operation of this essential pathway — and to providing insights into the development of targeted therapies.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

Glyceraldehyde -3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D - glyceraldehyde 3 - phosphate (G3P) into 3 - phospho - D - glyceroyl phosphate.

A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth - control pathway.

This in turn can provide insight into the key cellular pathways that are potentially amenable for therapeutic intervention.

For example, the insulin receptor substrate and phosphotyrosine binding proteins GAB1 / GAB2 emerged on the metazoan stem after the divergence of choanoflagellates, indicating that an insulin - signalling - like pathway may have been a key regulator of growth in early animals by tying into the ancient PDK1 and Akt kinases (Fig. 2b).

Several IFN signaling pathway — related key regulators, including STAT1, STAT2, IRF - 1, and IRF - 9, were transfected individually or in combination into STAT1 - deficient U3A cells, together with a luciferase reporter gene containing RIG - G promoter.

Ultimately, we aim to reveal the key species (cultured and uncultivated) involved in dental caries and provide new insights into specific genes / domains, gene products, and metabolic pathways that define the synergistic and competitive contributions to health and disease in this complex microbial community.

It is incorporated into key enzymes involved in several metabolic pathways implicated in thyroid hormone metabolism; additionally, it plays an antioxidant role in the regulation of the immune system.

Designer Whey Protein on the other hand, claims to have developed a formula with specific amounts of key ingredients (AKA Active Peptide Transport) that can help the paracellular pathway to dilate or open, and thus increase the speed which protein is absorbed into your muscles.

Many residents identify this strong financial support as a key reason why they chose SFTR over other pathways into teaching.

These principles are integrated into the initiative's key design pillars, which have set the foundation for innovative and responsive classrooms that provide personalized learning pathways for Birdville students.

Important findings and recommendations of the Gonski 2.0 report fall into a number of key areas that the Maths Pathway model addresses directly:

Options: Am / Fm Stereo W / Cd / Mp3 Player - Inc: Auto - Store Fm Diversity Antenna Auxiliary Input Located Inside Center Console Dvd Changer Prep Premium High - Fidelity 16 - Speaker Sound System - Inc: Digital Sound Processing (Dsp)(2) Subwoofers Under Front Seats 600 - Watt Digital 9 - Channel Amplifier Hd Radio W / Multicast Fm Station Reception Entertainment Server 12 Gb Hard Drive W / Usb Port For Media Transfer Body - Color Roof Trim Strips Power 2 - Way Tilt / Slide Glass Moonroof W / Key - Off & One - Touch Operation Sunshade Wind Deflector Body - Color Bumpers W / Hydraulic Energy Absorbers & (Front Only) Compressible Elements Power Adjustable Power - Folding Heated Auto - Dimming Body - Color Side - View Mirrors - Inc: 2 - Position Memory Rh Automatic Tilt - Down In Reverse Illuminated Exterior Door Handles & Ground Illumination Intermittent Rain - Sensing Windshield Wipers W / Adjustable & Vehicle - Speed - Sensitive Wiping Interval Single - Wipe Control Windshield - Washer System W / Heated Washer Jets 19 X 8.5 V - Spoke Light Alloy Wheels (Style 426)- Inc: P245 / 45R19 Run - Flat All - Season Tires Led Fog Lights Automatic Trunk Lid Open / Close Xenon Rain - Sensing Adaptive Headlights - Inc: Dynamic Auto - Leveling Corona Headlight - Rings & Cornering Lights Retractable High - Intensity Headlight Washers Body - Color Exterior Door Handles Adaptive Brake Lights Pathway Lighting Feature Programmable Via Vehicle & Key Memory Power Soft - Close Automatic Doors Dual Cupholders Front & Rear Front Visors W / Illuminated Vanity Mirrors Dynamic Cruise Control Expanded Check Control Vehicle Monitor System Power Windows - Inc: Key - Off Operation One - Touch Open / Close Anti-Trapping Feature Coded Driveaway Protection Ambiance Lighting In Front Rear & Door Panels Dual Illuminated Rear Vanity Mirrors Integrated Into Rear Cabin Roof Lining Vehicle & Key Memory Fully Finished Trunk Comfort Access Keyless Entry W / Multi-Function Remote Rear Center Armrest W / Storage Compartment Rear Window Defogger Auto - Dimming Rear - View Mirror 4 - Zone Automatic Climate Control - Inc: Draft - Free Vents Solar Sensor Automatic Recirculation Heat - At - Rest Feature Automatic Ventilation Electronic Analog Speedometer & Tachometer Anti-Theft Alarm System - Inc: Interior Motion Detector Owner's Manual Condition - Based Service Display W / Additional Functions Accessible Through Idrive System Central Power Locking System - Inc: Anti-Theft Feature Selective Unlocking Programmable Via Vehicle & Key Memory Nappa Leather Upholstery Black Panel Display W / Lcd Main & Trip Odometer Displays & Warning Indicators In Dial Faces Front & Rear Floor Mats Hard Drive - Based Navigation System - Inc: Voice - Command & Real Time Traffic Info Fineline High Gloss Wood Interior Trim Power Tilt / Telescoping Steering Column Remote Trunk Release Heated Front Seats W / Fast Heating & Balance Control Front Console Compartment - Inc: Coinholder Illumination Multi-Contour 20 - Way Power Front Bucket Seats - Inc: 4 - Way Pwr Lumbar Support Articulated Upper Backrest Adjustable Backrest Width Adjustable Thigh Support Driver & Front Passenger Seat Memory Active Head Restraints W / Adjustable Side Support Integrated Universal Garage Door Opener Multi-Function Sports Leather - Wrapped Steering Wheel - Inc: Audio Controls Phone Controls 2 - Position Memory Smokers Pkg Idrive System - Inc: On - Board Computer Controller (8) Programmable Memory Buttons 8 - Speed Automatic Transmission - Inc: Automatic & Manual Shift Modes Both W / Fully Synchronized Electronic Gear Changes Self - Leveling Air Spring Rear Suspension Rear Wheel Drive 4.4 - Liter Twinpower Turbo 32 - Valve 445 - Hp V - 8 Engine - Inc: Double - Vanos & Valvetronic Variable Valve Control High - Precision Direct Injection Dynamic Damping Control Driving Dynamics Control Front Multi-Link Double - Wishbone Aluminum Suspension Rear Multi-Link Integral - V Aluminum Suspension Brake Energy Regeneration To Convert Kinetic Energy Into Usable Electrical Pwr 4 - Wheel Ventilated Disc Brakes W / Electronic Brake Proportioning Twin - Tube Gas - Pressure Shock Absorbers Vehicle - Speed - Sensitive Variable - Assist Variable - Ratio Rack - & - Pinion Power Steering Auto Start - Stop Function Aluminum Front & Rear Subframes Electromechanical Parking Brake ** Preliminary Standard Equipment ** Front - Seat Side - Impact Airbags 3 - Point Safety Belt System - Inc: Alr In All Passenger Positions Rear - View Camera Child Safety Rear Door Locks Anti-Lock Braking System (Abs) Driver & Front Passenger Dual - Threshold Dual - Stage Front Airbags W / Passenger Occupant Sensor Front & Rear Head Protection System (Hps) Corona Ring Integrated Daytime Running Lights Front & Rear Park Distance Control W / Graphic Display Emergency Interior Trunk Release Handle Front Safety Belt Automatic Pretensioners Acoustic Belt Warning Active Protection Bmw Assist W / Enhanced Bluetooth & Usb - Inc: (4) Years Of Automatic Collision Notification Emergency Request Enhanced Roadside Assistance Remote Door Unlock Stolen Vehicle Recovery Customer Relations Teleservice Mobile Office Features Myinfo Lower Anchors & Tethers For Children (Latch) On Rear Outboard Seats Dynamic Stability Control (Dsc)- Inc: Brake Fade Compensation Start - Off Assistant Brake Drying Brake Stand - By Dynamic Traction Control (Dtc) Dynamic Brake Control Crash Sensor That Activates Battery Safety Terminal Disconnect Of Alternator Fuel Pump & Starter From Battery Automatically Unlocks Doors Turns On Hazard & Interior Lights Tire Pressure Monitor Active Knee Protection

• Provide a clear, evidence - based explanation of the role played by different parts of the energy sector in causing air pollution • Present detailed projections of the energy sector and related air quality pathways in different countries and sectors, based on known energy, climate and air quality policies, and the key implications for policymakers • Identify additional policy measures that can materially improve the outlook for energy - related air pollution, examining both the co-benefits and trade - offs with other energy and climate objectives • Based on analysis of different policy options, distil the key findings of the report into a clear set of implications and recommendations for policymakers

The ECMH - E ® will provide a pathway to Endorsement ® for professionals who incorporate key infant and early childhood mental health competencies into their work with and on behalf of children ages 3 up to 6 years old and their families.