«We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells
into kidney structures that resemble those found in a normal human kidney.
Not exact matches
But he eventually did get a measure of recognition: The Wolffian body, an embryonic
structure in animals that develops
into the
kidney, is named after him.
Using normal
kidney development as a roadmap, the BWH investigators developed an efficient method to create
kidney precursor cells that self assemble
into structures which mimic complex
structures of the
kidney.
In the mouse study, the insulin - producing cells were placed under the
kidney capsule — a thin membrane layer that surrounds the
kidney — where they developed
into an organ - like
structure with its own blood supply.
Contrast agents, injected
into the patient during an MRI procedure and designed to be quickly cleared from the body by the
kidneys afterwards, are needed to make fine details of organ
structures, blood vessels, and other specific tissues clearly visible in the images.
The results, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), point to new avenues for research
into the processes that direct cells to form functional
kidney structures.
With the loss of the cushioning effect provided by free - moving collagen in the blood vessels, the force of the surge of blood that is driven
into the arteries by the pumping action of the heart is carried directly to organs like the
kidneys and the brain, damaging to the
structures that filter our blood and that connect the functional regions of our brain, and putting us at risk of a stroke.