Transplanting gut flora from obese mice
into lean mice turned the formerly lean mice fatter... Compelling evidence that gut flora has an important connection to body fat levels.
Not exact matches
In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and
lean mice and transplanted them
into the guts of microbe - free
mice.
By comparing the behavior of XBP - 1s in the obese
mice with that in
lean, healthy ones, he discovered an inflammatory protein that modifies XBP - 1s in healthy animals so it can be shuttled
into the nucleus.
Both obese humans and
mice have significantly elevated soluble Fabp4 / aP2 levels, and injection of recombinant Fabp4 / aP2
into lean wild type
mice stimulates hepatic glucose production and gluconeogenesis.
Researchers at Washu took identical twins where one was
lean and other was obese, same genetic material transplanted the microbes
into germ - free
mice, and lo and behold, the
mouse who received the microbes from the obese twin gained weight without any change in diet.
Other studies have demonstrated that microbes implanted from
lean mice into overweight
mice caused the
mice to lose weight.
And wait we do; despite the
lean ninety - minute runtime, Downrange can't quite figure out enough variations on their cat - and -
mouse situation to keep the final two acts from devolving
into a boring slog.