In mice with an artificial fever, more lymphocytes (green) adhered to blood vessels (red) in lymphoid organs and crossed the vessels
into lymphoid tissue.
Evans» team had previously shown that fever also assists the passage of lymphocytes
into lymphoid tissue, but they hadn't figured out what was happening on a molecular level.
Immunologist Sharon Evans of Roswell Park Cancer Institute in Buffalo, New York, and coworkers are studying how fever affects the movement of white blood cells, or lymphocytes, from the blood
into lymphoid tissue, where they learn to recognize and fight pathogens.
Thus, blood cells can become sensitive to this death pathway if they come into contact with lymphoid cells, as would occur when blood CD4 T cells traffic
into lymphoid tissues.
Not exact matches
When injected together with factor VIII
into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the
lymphoid tissue that are responsible for initiating immune responses.
In pathological conditions, MSCs migrate preferentially
into lymphoid organs, allografts, injured and / or inflammatory
tissue sites after systemic transfusion, where they interact with the activated immune cells and modulate their function 51, 52.
We speculated that this could be due to the poor development of the
lymphoid tissues in these mice rather than the inherent inability of the HPCs to develop
into lymphoid cells.