Sentences with phrase «into lysosomes»

In collaboration with Columbia University's David Sulzer, Cuervo presented evidence of altered CMA in Parkinson's disease in 2004, and then in 2010 demonstrated that inefficient cargo loading of proteins into lysosomes could be responsible for the pathogenic accumulation of proteins inside cells of Huntington's patients.

Within the cell, the mineralized viruses enter into lysosomes, whose slightly acidic environment dissolves the mineral shell and releases the viruses.

A different branch of autophagy — a specialty of Cuervo's lab — involves molecular chaperones that escort misbehaving proteins through special tunnels into the lysosome.

It matures and turns into a lysosome.

The researchers speculate that if the doxorubicin can't be taken into the lysosome (essentially because propranolol got there first), it will be free to reach its target.

Not exact matches

Derived from Greek terms meaning «self - eating,» the autophagy system sends protein aggregates and malfunctioning cellular components into acidic compartments called lysosomes, where enzymes chew them up.

Immature dendritic cells (DCs) sequester intact antigens in lysosomes, processing and converting antigens into peptide — MHC II complexes upon induction of DC maturation.

The virus must then fuse with the lysosome membrane to escape into the host cell's cytoplasm, where it can multiply.

The CMG2 protein then acts as a receptor, sending a signal into the cell, causing collagen VI to be internalized and degraded inside the cell's lysosomes.

Northwestern Medicine scientists have discovered that two key cellular structures, called mitochondria and lysosomes, come into direct contact with each other in the cell to regulate their respective functions.

In the lysosome, bacteria are broken into their individual constituents, which can be reused by the body.

Scientists at the Max Planck Institute of Biochemistry in Martinsried, Germany, now discovered a new family of helper proteins that recognize labeled cellular protein waste and guide them efficiently to the lysosome for destruction and subsequent recycling into their reusable compounds.

One such system is the lysosome, a kind of cellular «incinerator» that contains the most powerful enzymes in the cell for breaking mangled molecules down into manageable pieces.

When he moved back to Tokyo in 1977 to the lab of Yasuhiro Anraku, Ohsumi continued with his new study subject, but worked on transport systems that moved small molecules like amino acids and calcium into and out of the yeast version of the lysosome (idiosyncratically known by yeast biologists as the vacuole — which means «empty space»).

However, approximately 40 % of human (and most eukaryotic) proteins localize to chemically distinct subcellular environments, including the organelles that compose the secretory pathway, endocytic vesicles, mitochondria, lysosomes or they are secreted into the extracellular milieu.