In the study, the researchers compared how well CRISPRi and CRISPR - Cas9 silenced a particular gene that controls iPSC pluripotency — the capability of iPSCs to turn
into multiple cell types.
Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate
into multiple cell types.
Stem cells possess the ability to differentiate
into multiple cell types.
These cells are cancerous yet have properties of stem cells: self - renewal and the ability to differentiate
into multiple cell types that occurs in tumors.
In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate
into multiple cell types.
Not exact matches
The work contradicts previous studies that found that
multiple types of unidentified supporting
cells transform
into hair
cells when Notch signaling is blocked.
Cancer
cells resemble stem
cells not because they can turn
into other
cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through
multiple layers of stop signs and barricades and just keep on multiplying.
Because most immune
cells typically can't get
into the brain, microglia are adapted to perform
multiple functions that are normally handled by several different
types of immune
cells.
Human mesenchymal stem
cells (hMSCs) are currently the most common adult stem
cell type used for
cell therapy applications due to their regenerative properties and ability to differentiate
into multiple cell lineages (adipocyte, chondro ¬ cyte, and osteocyte).
Current explorations
into the molecular underpinnings of
cell circuitry are leveraging
multiple data
types including expression profiling and epigenetic analysis leveraging RNA - seq and CHiP - Seq coupled with molecular markers and cellular phenotypes.
Recent studies have described a subpopulation of cancer
cells within tumors termed «cancer stem
cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate
into multiple cancer
cell types [1 — 7].
2) The iPSCs can be developed
into multiple tissue
types for studying the effects of mammoth mutations on the traits of
cells.