The effects of therapeutic lasers in wound healing include vasodilation, angiogenesis, increased collagen synthesis by fibroblast, differentiation of fibroblast
into myofibroblasts, stimulation of leukocytes, and enhanced antioxidant activity.
The researchers found that a specific stem / progenitor cell population was inhibited following radiation in mice missing Nrf2, and that alveolar type 2 cells in these mice were more likely to change
into myofibroblasts — a cell type implicated in fibrosis.
By 3 to 7 days, these cells differentiated
into myofibroblasts that secreted abundant extracellular matrix proteins and expressed smooth muscle α - actin to structurally support the necrotic area.
During fibrosis these cells differentiate
into myofibroblasts, causing scarring and organ failure.
Not exact matches
The first and most obvious use would be to develop a therapy that signals
myofibroblasts to convert
into adipocytes — helping wounds heal without scarring.
Once inside the
myofibroblasts, the virus downloads the transcription factors, which transform the cells
into hepatocytes.
The orbital remodeling in TED is likely induced by infiltrating T lymphocytes and mast cells, which activate orbital fibroblast effector cells to either proliferate and form scar - producing cells called
myofibroblasts or turn
into pro-inflammatory fat cells.