In organoids, the brain cells organize themselves — very similar to the process in the brain of an embryo: the stem cells divide; a proportion of the daughter cells
develops into nerve cells; these move to wherever they are needed.
In many nerve cells, magnesium serves as Nature's own calcium channel blocker, preventing calcium from
rushing into the nerve cell and activating the nerve.
In the current Proceedings of the National Academy of Sciences, biologists show that the herpes virus can shuttle human antipain genes
into nerve cells in mice, increasing their tolerance for pain.
They zeroed in on the serotonin transporter gene (HTT), which codes for a protein that re-absorbs
serotonin into the nerve cell after it has been released.
These findings, and others, show it is possible to get antisense
molecules into nerve cells, meaning improved versions should soon become available.
The tetanus toxin consists of two parts: One blocks the release from nerve cells of chemicals that stop muscles from contracting, leading to deadly spasms; the other mimics the structure of chemicals normally found in the brain, allowing the entire toxin to
slip into nerve cells.
As a graduate student at Stanford, he found ways to insert the gene of a light - sensitive protein found in
algae into nerve cells.
The virus is transmitted during sex; after infection, it
retreats into nerve cells that have their endings in the genital skin.
In contrast, CX546 increases nerve cell activity and calcium
influx into nerve cells by enhancing the activity of proteins called AMPA (α - amino -3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors.
Previous work had shown that the DNA region in question, a promoter located on chromosome 17, switches on a nearby gene coding for a protein that shuttles serotonin
back into nerve cells so they can reuse it as a neurotransmitter.
Studies also will allow scientists to track the molecular steps that the cell goes through as it
evolves into the nerve cell, or neuron, it produces.
Just this year, another group found that fibroblast cells (cells active in connective tissue) taken from mouse tails could be
made into nerve cells, or neurons.
A faulty
conduit into nerve cells that causes them to fire uncontrollably appears to trigger the brief seizures present in some forms of absence, or petit mal, epilepsy, say investigators from the...
The lab, called the MStem Cell Laboratories, derived embryonic stem cells from the embryo, and coaxed them to
grow into nerve cells.
In many nerve cells, magnesium serves as Nature's own calcium channel blocker, preventing calcium from
rushing into the nerve cell and activating the nerve.
Subsequently, the research group has begun studies on how these antennae - the primary cilia - regulate TGFβ - signalling during, among other processes, the transformation of stem
cells into nerve cells.
By reprogramming skin cells
into nerve cells, researchers at Karolinska Institutet are creating cell models of the human brain.
The team studied the anesthetic ketamine, which blocks NMDA (N - methyl - D - aspartate) receptor proteins that enable charged particles like calcium to flow
into nerve cells, like electric switches that trigger and shape messages.
Preliminary tests show that the newly created cells can develop
into nerve cells, heart cells, or any other kind of cell in the body.
Other researchers had successfully used a similar process to turn skin cells into embryonic - like cells called induced pluripotent stem cells, and then grow those iPS cells
into nerve cells, but Wernig's lab was the first to convert skin cells directly into nerve cells without the intermediate iPS cell step.
To these iPS cell lines the scientists added molecules known to guide mammalian pluripotent cells
into nerve cells.
Previous work from the Cambridge team has shown that transplanting neural stem cells (NSCs)-- stem cells that are part - way to developing
into nerve cells — reduces inflammation and can help the injured CNS heal.
It is now almost routine to grow skin cells from a patient with, say, a neurological disease; turn them into pluripotent cells in a Petri dish; convert the cells
into nerve cells to study the disease process; and contemplate using the cells to repair the same patient's damaged brain.
Her lab even turned those stem cells
into nerve cells and beating heart cells in a petri dish, she says.