The ability of scientists to convert human skin
cells into other cell types, such as neurons, has the potential to enhance understanding of disease and lead to finding new ways to heal damaged tissues and organs, a field called regenerative medicine.
Despite the complexity of the protein network associated with stem cell development, the team discovered that restoring only one interaction — between Grb2 and a protein known as Ptpn11 / Shp2 phosphatase — was enough to allow stem cells to again
change into other cell types.
Transplanting non-cardiac stem cells also increases the risk for tumor formation, as many of the cells
turn into other cell types besides the target heart cells.
When activated, these cells multiply and then
transform into other cell types required to replace worn out cells under conditions of normal tissue maintenance.
We're manipulating genes in the cell nucleus to produce specific proteins, changing the normal recipe for growth and maturation, and transforming adult cells into a new type of cell with the ability to
morph into any other cell type,» said Cooke, senior author and chair of the Department of Cardiovascular Sciences.
Because of the special ability of stem cells to self - renew and
differentiate into other cell types, the cells could theoretically start replicating out of control and form tumors themselves.
One potential treatment involves injecting the wound with stem cells, which can
change into other cell types, such as skin cells like keratinocytes, to help with the healing process.
Cancer cells resemble stem cells not because they can
turn into other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers of stop signs and barricades and just keep on multiplying.
Studying mouse embryonic stem cells, they removed Grb2, a protein essential to the ability of the stem cell to
transform into other cell types, from the cells.
The researchers from Australia and the Netherlands grew their «kidney - like structure» from induced pluripotent stem (iPS) cells — adult cells reprogrammed into a neutral state from which they can be coaxed to
develop into other cell types.
Some of the researchers at the centre will study the differentiation of stem
cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.
By designing synthetic proteins that can only interact with a pre-determined partner, and introducing them into cells, the team revealed a key interaction that regulates the ability of embryonic stem cells to change
into other cell types.
Sasai, who worked at the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, was famous for his ability to coax embryonic stem cells to differentiate
into other cell types.
The study of mice suggests that a high - fat diet drives a population boom of intestinal stem cells and also generates a pool of other cells that behave like stem cells — that is, they can reproduce themselves indefinitely and differentiate
into other cell types.
The model that the 4D Genome team used was cell reprogramming, a process that allows the scientists to revert white blood cells back to a state of pluripotency whereby these cells can differentiate
into any other cell type.
«Our approach could lead to a simpler method of creating iPSCs or could be used to directly reprogram skin cells
into other cell types, such as heart cells or brain cells.»
«We wanted to know how the epigenome of a differentiated cell that's programmed to perform a specific job differs from the epigenome of a pluripotent stem cell, that has the potential to turn
into any other cell type,» Lister says.