Sentences with phrase «into preclinical»
Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.
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The findings discovered in animal models are translated into preclinical mechanism - driven prevention studies that will ultimately inform epidemiologic studies and lead to clinical trials in humans.
If too few MDs go into preclinical research, this field will lose valuable input, many believe.
Not exact matches
«What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,» Shenoy said.
Medicinal cannabis use is booming for many disorders, the authors of the paper said, even without enough preclinical evidence or sufficient insights into its mechanism of action.
Ojima says, «Once we have drug candidates that are ready to go into animal models, preclinical studies, toxicology, and such things, it really takes companies to do that.»
Researcher Omkar Patkar said the preclinical study is the first step towards fast tracking pindolol into human clinical studies as a treatment option for AUDs.
Before PCSK9 inhibitors can be approved for widespread use, further research into PCSK9 function using suitable preclinical models is needed.
The research into quantum dots containing single magnetic ions was funded with grants from the Polish National Science Centre and the Polish National Centre for Research and Development, as well as project funds from the Centre for Preclinical Research and Technology.
«Despite extensive preclinical approaches, translation of gene therapy strategies into clinical trials is still a difficult and expensive process.»
The American Heart Association / American College of Cardiology (AHA / ACC) has categorized HF into three stages (A, B, C / D) with A and B being preclinical phases, meaning they are characterized by elevated risk of HF without the actual condition.
Yet, the fundamental insights into the mechanisms of metastasis will pave the way for the rationale translation of these preclinical discoveries into clinical application.»
«We are pleased to have obtained the same results in two different laboratories and we look forward to translating these preclinical findings into combination approaches with entinostat to enhance the clinical activity of immune checkpoint inhibition.»
Besides carrying out experimental and clinical pain studies, Dr. Arendt - Nielsen's unit also helps companies translate basic preclinical findings into clinical trials.
They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.
PsychoGenics has pioneered the translation of rodent behavioral responses into robust, high throughput, high content phenotyping and its drug discovery platforms, SmartCube ®, NeuroCube ®, and PhenoCube ® have led to shared risk partnerships with major pharma companies such as Sunovion and Roche and resulted in the discovery of several novel compounds now in clinical trials or advanced preclinical development.
These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.
Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.
In collaboration with the University of Massachusetts Medical School (UMMS) and Auburn University (AU), Lysogene is developing IND - supporting preclinical studies using AAV gene therapy technology to translate the initial proof of concept into a viable drug development program to the benefit of patients in urgent need.
This study is a beautiful example of multidisciplinary team science at partnering academic institutions advancing a life - saving therapeutic from the laboratory, to preclinical studies, deftly though complex regulatory pathway, to the clinic and — with final FDA approval — hopefully into the marketplace.
Roche (SIX: RO, ROG; OTCQX: RHHBY) and Prothena Corporation plc (NASDAQ: PRTA), announced today that they have entered into a worldwide collaboration to develop and commercialize antibodies that target alpha - synuclein, including PRX002... which is currently in preclinical development and is expected to enter Phase 1 clinical trials in patients with Parkinson's disease in 2014.
«So far, there has been a poor track record of moving things from preclinical discoveries into successful clinical trials,» says senior author Steve Finkbeiner, MD, PhD, a senior investigator at the Gladstone Institute of Neurological Disease and a professor of neurology and physiology at UCSF.
These new preclinical studies provide support for advancing the Ad26 / MVA prime - boost vaccine candidate into clinical development.
Their purpose is to facilitate the preclinical and clinical research needed to translate the ideas generated through basic research into safe and effective drugs, vaccines, and diagnostics to control and prevent allergic, immunologic, or transplantation - related diseases and conditions.
Associate Senior Lecturer (Assistant Professor) in Molecular Medicine: Translation of preclinical regenerative medicine into advanced therapy medicinal products (ATMP)(PA2018 / 376)
«We are hopeful these exciting preclinical results will translate into clinical benefit for patients.
Radiographic results can be used in conjunction with other diagnostic tools, such as auscultation and echocardiogram (ECHO), to confirm if a dog is developing heart disease and if so, if the dog is at the preclinical stage (eg, B1 or B2) or has progressed into heart failure.
Very few of the leads developed in preclinical research ever get into clinical trials.
Pain and the Reward Pathway: Preclinical Studies on the Impact of Pain on Opioid - Seeking Behavior Learn about the functional relationship between pain, opioid receptor dysregulation, and motivated and affective behavior, providing new insights into the critical neurochemical and neuroanatomical mechanisms that underlie pain - induced changes in opioid reward and comorbid affective disorders.