Sentences with phrase «into rodent models»

Extending these results into rodent models of H. pylori - induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

Not exact matches

The discovery in a rodent model may provide insight into what happens in the visual systems of children born with a condition that prevents the optic nerve from fully developing.

This work illustrates how the study of inbred canine populations can provide new insights into the genetic underpinnings of complex disease, bridging the gap between small rodent models and humans.

Although researchers found that delivering the Isis drug directly into the brain nearly doubled survival time in a mouse model of SMA3, systemic administration in the rodents — which usually die within two weeks — has been shown to extend median survival by up to eight months.

Rodent models can't capture the years long path of human brain development, but 3D human organoids now give researchers a window into later stages of development of our burgeoning central nervous system.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38

In rodent models of lipodystrophy, researchers transplanted a little bit of fat back into the fat - free mice.

Therapeutics targeting microglia have slowed disease progression in rodent models, but have failed to translate into effective therapy for ALS patients.