Sentences with phrase «into stem cell niche»

This week's Journalstream spans stem cell research advances in the liver and the brain, as well as describes critical insights into stem cell niche formation.

Not exact matches

Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.

Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.

This research provides new insights into the structure of the stem cell niche in health and after injury.

While it is generally accepted that MSC are mostly quiescent during postnatal life, MSCs in different niches can presumably differentiate into the specific cells of closely related niches during physiological turnover, injury or disease, as shown for other stem cell types (e.g., muscle satellite cells).

The other one, the finding by the Clevers group in Utrecht that adult Lgr5 + stem cells from the intestine, grown 3D in the presence of basement membrane matrix and a defined set of niche factors, can develop into ever - expanding, genome - stable 3D organoids that resemble the structure and function of the original intestinal epithelium (13 - 16).

Stem cells are encapsulated into niches made from materials designed to mimic the natural extracellular matrix.

Research in his Laboratory of Stem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ceStem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ceCell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cestem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cecell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cestem cells.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.