«Knowing the cell of origin of cancer cells can provide insight
into tumor subtypes and possibly diagnostic and therapeutic benefit,» says JAX Assistant Professor Jennifer Trowbridge, Ph.D., the lead author of the study published on July 11 in Nature Communications.
Not exact matches
Human breast cancers can be classified according to their histological and molecular features
into different
subtypes, including luminal, ERBB2 and basal - like
tumors.
This finding allowed their team to classify
tumors into four major molecular
subtypes, which could also lead to developing new therapies.
«Researchers inhibit
tumor growth in new
subtype of lung cancer: Insight
into tumor suppressing and
tumor promoting mechanisms offers potential for new treatments.»
A team of UNC researchers and collaborating researchers from three other institutions — Washington University in St. Louis, the University of Utah and the BC Cancer Agency — designed this test that categorizes breast
tumors into one of four main
subtypes by looking at the expression of 50 genes.
The team found that ccRCC
tumors fall
into different evolutionary
subtypes that are associated with distinct clinical phenotypes.
«Our data suggests that human
tumors can be divided
into two major
subtypes, the let - 7hi and let - 7lo - expressing
tumor cells,» the authors write.
A network of transcription factors may drive different
subtypes of aggressive bladder cancer, allowing researchers to turn one type of
tumor into another
The data presented in this article suggests that
tumor subtype needs to be taken
into account during treatment design as blocking angiogenesis and therefore increasing
tumor hypoxia may be beneficial in the treatment of ER - α — negative breast cancer but could have catastrophic effects on ER - α — positive breast cancer.