Once home, the cells proliferated and matured
into viable eggs and sperm.
Not exact matches
In the initial work at the Roslin Institute, the
egg cells along with their transplanted nuclei were then implanted directly
into a foster mother, where they developed and, in the case of Dolly, resulted in a
viable offspring.
The embryonic cells can develop
into replacement organs in the lab or be injected
into an
egg, where they develop as a
viable embryo and are literally born.
To prove that these artificial PGCs were faithful copies, however, they had to be shown to develop
into viable sperm and
eggs.
They simply used the jellyfish gene, which is easily detected, to test whether inserting foreign genes
into eggs (so - called germline gene alteration) can produce
viable monkeys.
ICSI involves selecting a single
viable sperm cell that is then injected
into the
egg through a needle.
In the 1960s, he transplanted nuclei from frog intestine and skin cells
into frog
egg cells and created a
viable animal.
There, the sperm prematurely fertilized the
eggs, which were then unable to develop
into viable offspring.
If the cells can be fertilized and develop
into viable embryos, and if human ES cells turn out to have similar powers, such cells could allow researchers to get around some of the expense and ethical questions that arise from using donated
eggs for therapeutic cloning experiments.
Thus far, the Newcastle team has worked with abnormally fertilized human
eggs that will not develop
into viable embryos; the new money will allow them to use normal, leftover
eggs from IVF therapy.
For their part, the researchers believe that once they sort out the technical issues of getting an
egg subjected to these IVF procedures to develop
into a normal,
viable embryo, the benefits of allowing a couple to have a healthy child far outweigh other risks or ethical concerns.