Sentences with phrase «intracellular cholesterol accumulation»
Furthermore, translocation of several cholesterogenic enzymes from the endoplasmic reticulum to other cell compartments can occur under various conditions, thereby regulating levels and sites of intracellular cholesterol accumulation.
http://www.asbmb.org/ Not exact matches
They suggest that the effects on lysosomes are secondary to reduced Aβ accumulation, but I suspect the causation may work in the reverse direction, since they found that HBCD lowered cellular membrane cholesterol, and abnormally high lysosomal membrane cholesterol can impair the acidification and function of lysosomes, which are necessary for clearance of intracellular Aβ.