Sentences with phrase «intracellular levels»

From plants to metazoans, an increase in intracellular levels of NAD + directs cells to make adjustments to ensure survival, including increasing energy production and utilization, boosting cellular repair, and coordinating circadian rhythms.

Bach1 and its ligand coordinate the overall intracellular levels of heme and iron with anti-oxidant gene expression [23], [24].

The researchers demonstrated with in vitro and cell culture studies that sNOOOpy can monitor intracellular levels in the micromolar range of nitrate and nitrite in real time.

We also have research interests in cellular regulation by ADP - ribosylation, which links epigenetics to metabolism; NUDIX hydrolases, which are involved in regulating intracellular levels of various nucleotides; and sphingolipid biosynthesis, which has strong links to both inflammation and cancer, and where mutations in the various proteins involved are associated with a variety of rare diseases.

Therapeutically, NAC is often used to help replenish intracellular levels of glutathione, to mitigate oxidative damage and to help support healthy lung and bronchial function.

This process also prevents intracellular levels of ADP from elevating which can decrease power output by decreasing cellular respiration and speeds up energy requirements (4).

Thus Bach1 coordinates the overall intracellular levels of hemin and iron metabolizing genes with anti-oxidant gene expression [19], [21], [22], [24].

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

«The urine metabolites can indicate the underlying function of the kidney at a biochemical and intracellular level,» he said, «and are well - conserved compared to many cell - based and protein measurements.

Norepinephrine causes a four - to sixfold increase in the intracellular level of cyclic AMP (adenosine 3», 5» - monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain.

Intracellular level of Mg increased rapidly in the magnesium infusion group 15 minutes post infusion and continued to rise throughout the 6 - hour observation period.

Intracellular levels of NAD + regulate immune and inflammatory pathways, including the cytokine TNF - alpha, a critical signaling molecule.34, 35

Upon oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, uric acid, vitamin E, and glutathione.