Sentences with phrase «intracellular signaling pathway»

Due to reduced mTOR activity, a key intracellular signaling pathway regulator, the function of the cell's power plants, the mitochondria, is disrupted.

Here, Dr. Tam presents data characterizing the intracellular signaling pathway associated with the RANK — RANKL axis, as well as the effect in dendritic cells, antigen - specific T cells, cytokines, and chemokine profiles after in vivo treatment with blocking PD - L1 and T cell - depleting antibodies in a melanoma cancer model.

Researchers have discovered that genetic mutations underlying two inherited eye disorders arise in different components of a single intracellular signaling pathway that is responsible for development...

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

Anne Meyer (Reichmann, TUD)-- «Intracellular signaling pathways in the dopaminergic specification of fetal mesencephalic neural stem cells» (2009)

The accumulation of calcium can then regulate the contraction of muscles, trigger the release of neurotransmitters or hormones, modulate intracellular signaling pathways, and impact several other calcium - dependent cellular functions.

Important advances have included the discovery of the first evidence that the odour response is governed by neurons, of the intracellular signalling pathways between odorant receptors and sensory neurons, and of specific neurons, receptors and neurotransmitters involved in behaviour adaption following experience.

With similar precision, Professor Bargmann has also identified many of the intracellular signalling pathways in C. elegans that relay information from cell surface odorant receptors (G protein - coupled receptors) to the interior of each sensory neuron.

Rigel Pharmaceuticals focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms.

Not exact matches

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

Biology is rife with examples of modularity: the overwhelming majority of molecules in a cell is either part of an intracellular complex with modular activity, such as the ribosome, or participates in an extended (functional) module as a temporally regulated element of a relatively distinct process (e.g., signal amplification in a phosphorylation ‐ mediated signaling pathway).

This gene is believed to signal availability of other substances, like oxygen, and to interact with intracellular pathways regulating growth and nutrient uptake in other tissues of the body.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

The fat body senses the concentration of intracellular amino acids through the activity of the Target of Rapamycin (TOR) signaling pathway, which in turn regulates the synthesis and secretion of an undescribed humoral factor (s), called the fat - body — derived signal.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

The extrinsic apoptotic pathway is activated by external signals through transmembrane tumour necrosis factor receptors (TNFRs) whose intracellular death domain interacts with downstream adaptors.

The discovery of EPAC as an additional intracellular cAMP receptor [29], the finding that cAMP - induced PKA (but not EPAC) signaling is coupled to the p38 MAPK pathway in some cell types [30], and the observation that SB202190 partially, but not completely, inhibited 8 - Br - cAMP - stimulated Oct4 activity (Figure 4D) led us to ask whether all of the 8 - Br - cAMP response was mediated through PKA / p38 MAPK.

While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators of intracellular signal transduction pathways that are typically associated with growth - promoting hormones such as insulin and IGF - 1.

Intracellular levels of NAD + regulate immune and inflammatory pathways, including the cytokine TNF - alpha, a critical signaling molecule.34, 35