Sentences with word «intraperitoneal»

Furthermore, toxicity analysis carried out 9 days after the last dose of intraperitoneal injection of 2 μg / g body weight revealed little or no changes in > 98 % of the markers characterized in a complete blood count (Supplemental Fig. 7).

General anesthesia was induced by intraperitoneal injection of pentobarbital sodium (Sanofi, Libourne, France) just before killing by exsanguination.

He is an expert in regional perfusion including hyperthermic intraperitoneal chemotherapy (HIPEC), a technique that delivers high doses of heated chemotherapy directly to abdominal organs to kill cancer cells that may remain after surgical removal of visible tumors.

This study is the first to compare the effects of the well - known DPP - IV inhibitors diprotin A and sitagliptin on emotional and motivational behavior in rats after subchronic intraperitoneal administration of the drugs in the early postnatal period.

The authors administered NK cells via intraperitoneal injection into a xenograft mouse model established using bioluminescent ovarian cancer cell lines which allow for tumor monitoring via bioluminescent imaging (BLI).

Similarly, relapse - free survival for those receiving intraperitoneal chemo was 23.8 months compared with 18.3 months for the intravenous - alone group, a 20 percent improvement.

We have made progress in the safe use of advanced surgical procedures and can now combine surgery with heated intraperitoneal chemotherapy for selected patients with ovarian cancer.

For intraperitoneal glucose tolerance testing (IPGTT), mice were fasted overnight, and preinjection blood samples were rapidly collected from the tail vein within 3 minutes of cage disturbance, as previously described (37).

Worked in a group environment to perform various laboratory techniques on mice, including intraperitoneal injections and submandibular bleeds

Female Dark Agouti rats (110 — 150 g) were orogastrically gavaged with emu oil (0 · 5 or 1 ml) or water (1 ml) for 5 d before intraperitoneal injection of 5 - fluorouracil (5 - FU, 150 mg / kg) or saline (control), and this was continued up to the day of sacrifice (48, 72 and 96 h post 5 - FU administration).

and massive intraperitoneal haemorrhage?.

In animals harboring intraperitoneal hollow - fiber or subcutaneous implants containing light - inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote - controlled with fiber optics or transdermally regulated through direct illumination.

Corresponding authors Olena Taratula and Oleh Taratula of the Department of Pharmaceutical Sciences and their collaborators evaluated the platform in vitro and in two different mouse models, including one that mimicked ovarian intraperitoneal metastasis.

Sacrifice at 15 days showed that daily intraperitoneal injections of statin into these mice recovered bone length (figure 1).

After collecting the first sample, mice were injected with 1.0 g / kg glucose in sterile saline [intraperitoneal (IP)-RSB-, and postinjection samples were taken at 30, 60, and 120 minutes.

We will perform intraperitoneal injections of antigen into mice to elicit an immune response for the production of monoclonal antiodies.

A key feature of our program is the availability of HIPEC (hyperthermic intraperitoneal chemoperfusion), a targeted treatment that delivers heated chemotherapy directly into the abdomen to kill residual cancer cells after tumor removal surgery.

Preliminary pharmacokinetics suggest a 1.89 - hour half - life in the blood (Supplemental Fig. 6D), and chronic experiments using RIPK2 inhibitor 1 agree with our preliminary pharmacokinetics, suggesting the efficacious quality of this inhibitor can last for up to 5 — 6 days after a 1 — 2 - μg / g body weight intraperitoneal injection (data not shown).

He beat it after undergoing heated intraperitoneal chemoperusion (HIPEC), or chemo bath.

To prepare ORO virus hyperimmune ascitic fluid for classical cross-neutralization tests, mice received 4 weekly intraperitoneal (IP) injections of virus - infected newborn mouse brain suspension with Freud's adjuvant.

Additionally, studies have shown that decreasing serotonergic activity through intraperitoneal (IP) administration of a serotonergic antagonist increases the amount of time that rodents can run before they reach the point of exhaustion [219].

Oral, subcutaneous, intravenous, intraosseous, and even intraperitoneal routes are all used, depending on the species receiving fluid therapy and why it is needed.

Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets

Before onset of clinical signs in littermates or other nearby puppies, rearing in incubators at an increased temperature (95 °F [35 °C], 50 % relative humidity), and / or passive immunization with intraperitoneal serum may reduce losses within an exposed litter.

An animal study showed that curcumin administered via intraperitoneal injection (injection into body cavity) improved joint inflammation more significantly than the oral route; 75 % and 48 % respectively.

Hyperthermic intraperitoneal chemotherapy, which delivers therapy directly to cancers that have spread to the abdominal wall, is another advanced treatment available at NYU Langone Hospital — Brooklyn.

Intraperitoneal administration of insulin to control rats and to rats with pituitary stalk transections or with lesions of the median eminence resulted in increased plasma adrenocorticotropin (ACTH) levels.

C, MCF7 xenografts were treated with YC1 by intraperitoneal injection before collection for mammosphere culture (i) and Glut1 measurement (ii).

Intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance in liver nuclei of three tyrosine phosphorylated proteins (84, 91, and 92 kilodaltons) within minutes after administration of EGF.

Women with Stage III ovarian cancer given a combination of intravenous and intraperitoneal chemotherapy following surgical debulking of tumor had a median survival nearly 16 months longer than women who received IV chemotherapy alone, according to a study published conducted by the Gynecologic Oncology Group (GOG), a National Cancer Institute - supported research network, in the January 5, 2006 issue of the New England Journal of Medicine.

Intraperitoneal injection of ODS significantly decreased chorda tympani nerve response magnitude to acids (sour tastants), as well as NaCl (Fig. 6C, Table 4).

Mice were anesthetized systemically with an intraperitoneal (i.p.) injection of 80 mg / kg of ketamine HCl (Fort Dodge Laboratories, Fort Dodge, IA) and 8.0 mg / kg of xylazine (Bayer Corporation, Shawnee Mission, KS).

Following two weeks of treatment, memory impairment was induced by intraperitoneal (i.p.) injection of scopolamine (1 mg / kg) 30 minutes prior to each of the following behavioral tests: Y - maze, probe trial of the water maze and contextual and cued fear conditioning.

To determine relevance in vivo, A / J (000646) mice were infected either by intraperitoneal injection with free MRSA or by tail vein injection with MRSA - infected macrophages.

Some animals were given an intraperitoneal injection of l - DOPA (25 mg / kg) and benserazide (5 mg / kg) after their first set of trials and then subjected to four to seven more trials 30 min following the injection.