Sentences with phrase «introduce point mutations»
That can make it hard to make subtle changes to a gene — like introduce point mutations corresponding to natural variations linked with human disease — without taking a sledgehammer to the entire gene locus.
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The most pivotal of those experiments involved the development of a novel «knock - in» mouse model in which a point mutation was introduced in GRK2 to prevent NO from binding (a process called nitrosylation).
Oligonucleotidedirected mutagenesis with the bacteriophage M13 system (Amersham) was used to introduce five point mutations into the coding regions of tat and rev. Alows stud