In black South Africans and in Zimbabwe, however, syphilis prevalence remained around 6 % until 50 years after
the introduction of penicillin.
The introduction of penicillin in the 1940s led to the selection of S. aureus strains that carried the methicillin resistance gene.
Not exact matches
The major mechanism
of resistance involves the
introduction of mutations in genes encoding
penicillin - binding proteins.
The discovery
of penicillin about 90 years ago and the widespread
introduction of antibiotics to combat infectious diseases have revolutionized human medicine.
Rather it was the widespread use
of first generation beta - lactams such as
penicillin in the years prior to the
introduction of methicillin, which selected for S. aureus strains carrying the mecA determinant.