Sentences with phrase «inverse agonists»
Inverse agonists are a type of medication or substance that produces the opposite effect compared to normal. They work by binding to certain receptors in the body and reducing their activity, as opposed to enhancing it like agonists. In simple terms, they do the opposite of what regular medicines do, decreasing the activity of specific receptors rather than increasing it. Full definition
Antiobesity efficacy of a novel cannabinoid - 1 receptor inverse agonist, N --LSB-(1S, 2 S)-3 -(4 - chlorophenyl)-2 -(3 - cyanophenyl)-1-methylpropyl]-2-methyl-2 --LSB-[5 -(trifluoromethyl) pyridin -2-yl] oxy] propanamide (MK - 0364), in rodents.
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We report the crystal structure of a human β2 - adrenergic receptor — T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution.
Following postdoctoral training at the State University of New York, Stony Brook with Masayori Inouye, he joined the Schering - Plough Department of Immunology, where he characterized the biology of a new class of cannabinoid CB2 receptor - specific inverse agonists.
The use of peripherally - restricted inverse agonists in diet - induced obese mice reduces appetite, body weight, hepatic steatosis, and insulin resistance (PubMed: 22841573).
Almirall S.A. and Nuevolution A / S have entered into a global strategic collaboration focusing on the development and commercialization of Nuevolution's novel RORγt inverse agonist (inhibitor) program for treatment of inflammatory skin diseases and disorders as well as for treatment of psoriatic arthritis.
S32212, a novel serotonin type 2C receptor inverse agonist / α2 - adrenoceptor antagonist and potential antidepressant: II.
AM6538, is an antagonist / inverse agonist that binds tightly to the receptor; it has a long half - life, making it potentially useful as a treatment of addiction disorders.