Sentences with phrase «involve additional genes»

Not exact matches

Many of the additional 38 missing genes looked like they coded for proteins involved in controlling the activity of other genes.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

Additional analysis showed that bile acid levels and genes involved in bile - acid regulation were changed in the offspring exposed to the maternal high - fat diet.

Next they tested an additional 27 genes that are known to be involved in various steps of ribosome biogenesis to verify whether SSUP was required for ESC maintenance.

When the researchers looked at the role of genes that were methylated by genes with code differences related to ASD, including additional genes beyond those with direct code changes, they found that the majority were involved in biological pathways that were important in immune function.

Another involves an additional copy of the p53 gene, inserted without disrupting the existing regulatory process that manages p53 levels.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

This observation suggests that the bulk of genes involved in Nasonia immune response remain uncharacterized, with the current study being the first identification of additional candidate genes for immunity based on functional response to infection.

To further investigate additional similarities between hNSCs and hESCs at the transcriptional level, we analyzed the expression of key genes involved in hESC self - renewal and pluripotency utilizing semi-quantitative RT - PCR analysis.

These laboratories are complemented by several additional laboratories: one that is focused on computational structure prediction and design (Phil Bradley), one that conducts solution - based protein mapping studies of large complexes involved in gene transcription (Steve Hahn) and a third that conducts drug target validation and drug screening studies (Julian Simon).

Vogelstein has gone on to investigate additional genes involved in colon cancer such as APC, mutations of which lead to colorectal tumors, and PIK3CA, whose mutations turn benign tumors malignant.

But having those gene variants doesn't mean you'll get celiac disease, which suggests that additional factors must be involved.