Sentences with phrase «involve change in states»

Not exact matches

Certain matters discussed in this news release are forward - looking statements that involve a number of risks and uncertainties including, but not limited to, doubts about the Company's ability to continue as a going concern, the need to obtain additional funding, risks in product development plans and schedules, rapid technological change, changes and delays in product approval and introduction, customer acceptance of new products, the impact of competitive products and pricing, market acceptance, the lengthy sales cycle, proprietary rights of the Company and its competitors, risk of operations in Israel, government regulations, dependence on third parties to manufacture products, general economic conditions and other risk factors detailed in the Company's filings with the United States Securities and Exchange Commission.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

It is impossible to make forecasts because we don't know the change in behaviour that this could cause in the manufacturing sector or in Canada, given that they could find other markets, other value chains elsewhere in the world that do not involve the United States.

Pulling the same legal levers as those involved in its climate change investigation of ExxonMobil, the New York state attorney general's office obtained an agreement from coal giant Peabody Energy to end misleading statements and disclose risks associated with global warming.

Wendy and I want to thank everyone who participated in the Change Their Story campaign, either by giving money or by becoming aware of the child sex slavery problem here in the United States and purposing to get involved in some way in the future.

But social change in the modern era is increasingly characterized by the intended and unattended consequences of planning, and such planning typically involves agencies of the central bureaucratic state.

He states that a man may have immediate awarenesses of two kinds: intuitive awareness of his own thoughts and feelings and sympathetic awareness of certain changes in parts of his body.21 The second type of direct human awareness involves the principle that the objects immediately known in sensation or perception are always objects inside the body and never objects outside the body.

The longing to move out of time (which involves change and so is «bad») into a state of timeless permanence (which is therefore «good»)-- characteristic of most post-Aristotelian philosophy and much contemporary Christianity — is thus seen to have more in common with Platonic dualism than with biblical witness.

Computer models being investigated both in the US and in the Soviet Union were demonstrating that a nuclear war involving the exchange of a small fraction of the total American and Russian bombs could change the climate of the entire Northern Hemisphere, shifting it abruptly from its present seasonal state to a long, sunless, frozen night.

«Capital Distributing has been involved heavily in the growth and transformation of the brand offerings in the state as well as the growth change that consumers are demanding,» Green says.

Arsene has already stated that they have secured qualification and no hurry to finish second.He will make 5 changes to the gala match and 3 to the dortmund clash with some players involving yaya sanogo at the final fixture alongside arteta, monreal, wilshere, gnabry as well as rosicky, so guys there you have it an more predictable side placed in front of you!

The administrators responsible all went to jail, the actual perp went to jail, the fine was donated to several charities across the state, every survivor that came forward, regardless of whether they were involved with Penn State in any way shape or form got a settlement, they implemented all the recommended changes over three years to ensure this doesn't happen astate, every survivor that came forward, regardless of whether they were involved with Penn State in any way shape or form got a settlement, they implemented all the recommended changes over three years to ensure this doesn't happen aState in any way shape or form got a settlement, they implemented all the recommended changes over three years to ensure this doesn't happen again.

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

I / we agree that if any material change (s) occur (s) in my / our financial condition that I / we will immediately notify BSHFC of said change (s) and unless Baby Safe Homes Franchise Corporation is so notified it may continue to rely upon the application and financial statement and the representations made herein as a true and accurate statement of my / our financial condition.nI / we authorize Baby Safe Homes Franchise Corporation to make whatever credit inquiries / background checks it deems necessary in connection with this application and financial statement.nI / we authorize and instruct any person or consumer reporting agency to furnish to BSHFC any information that it may have to obtain in response to such credit inquiries.nIn consideration of the ongoing association between Baby Safe Homes and the undersigned applicant (hereinafter u201cApplicantu201d), the parties hereto have entered into this Non-Disclosure and Non-Competition Agreement.nWHEREAS, in the course of its business operations, Baby Safe Homes provides its customers products and services which, by nature of the business, include trade secrets, confidential and proprietary information, and other matters deemed material or important enough to warrant protection; and WHEREAS, Applicant, by reason of his / her interest in Baby Safe Homes and in the course of his / her duties, has access to said secrets and confidential information; and WHEREAS, Baby Safe Homes has trade secrets and other confidential and proprietary information, including procedures, customer lists, and particular desires or needs of such customers to which Applicant has access in the course of his / her duties as an Applicant.nNow, therefore, in consideration of the premises contained herein, the parties agree as follows Applicant shall not, either during the time of his / her franchise evaluation with Baby Safe Homes or at any time thereafter either directly or indirectly, communicate, disclose, reveal, or otherwise use for his / her own benefit or the benefit of any other person or entity, any trade secrets or other confidential or proprietary information obtained by Employee by virtue of his / her employment with Baby Safe Homes, in any manner whatsoever, any such information of any kind, nature, or description concerning any matters affecting or relating to the Baby Safe Homes business, or in the business of any of its customers or prospective customers, except as required in the course of his / her employment by Baby Safe Homes or except as expressly authorized Baby Safe Homes Franchise Corporation, in writing.nDuring any period of evaluation with Baby Safe Homes, and for two (2) years thereafter, Applicant shall not, directly or indirectly, induce or influence, divert or take away, or attempt to divert or take away and, during the stated period following termination of employment, call upon or solicit, or attempt to call upon or solicit, any of the customers or patrons Baby Safe Homes including, but not limited to, those upon whom he / she was directly involved, or called upon, or catered to, or with whom became acquainted while engaged in the franchise evaluation process of a Baby Safe Homes franchise business.

«He's involved, he's getting his degree, he's taking the SNS exam at our state show in June — he was going to do it in San Antonio, but our schedule was changed and our flight doesn't work — he helps me do menu plans, back house setup for our software system, he's doing a salad bar roll - out — Chris has just really stepped up, really helped,» said Kroeger.

I asked if the decision to get involved at the federal level at a time when the GOP has a full slate of statewide candidates and is battling to retain and / or improve its slim hold on shared control in the state Senate indicates that Faso doesn't think much of his fellow Republicans» changes at the state level, and he insisted that was not the case.

Higher education institutions should take the lead on ending discrimination — and on the ESPY awards just a few night's ago Carmelo Anthony stated that athletes have to get involved in promoting desirable change.

He did say he did not expect any such changes to occur in a special session, and said there are many unanswered questions about the parameters in which a state - level special prosecutor — perhaps the attorney general, or some newly appointed official — would become involved in a case.

The climate - changing juggernaut snuck back into town in November via a letter from the New York State Thruway Authority to all «involved agencies» (municipalities that lie along the Thruway, which is the chosen route to transport Bakken crude oil between Albany and the New Jersey refineries) requesting approval as lead agency in the environmental review required before construction of the pipeline can be approved.

Initially he suggested Ted Cruz's father was involved in the assassination of JFK, perpetuated the myth of Obama not being born in the United States (which he later conceded) and repeatedly claimed climate change as a hoax all of which are the preserve of fake news websites.

For the JSCB's second phase, which will involve roughly $ 300 million in school renovations, state legislators changed the mandated composition of the board to give Miner and Contreras control over its composition.

The main change in the bill involves more the money from the federal government for states to subsidize coverage for the sickest citizens.

Governor Andrew Cuomo recommended a slew of changes to New York law in his State of Opportunity Agenda today, but the only major new proposal in the area of government reform involves increasing the pay for state legislaState of Opportunity Agenda today, but the only major new proposal in the area of government reform involves increasing the pay for state legislastate legislators.

Groups involved in the Convergence include the Green Shadow Cabinet, Organic Consumer Association, Poor People's Economic Human Rights Campaign, PopularResistance.org, System Change Not Climate Change, Alliance for Global Justice, Workers United, Sierra Club Atlantic Chapter, and many state Green Parties.

She tries to broaden the range of groups involved in climate change research, and works with federal, state and municipal government agencies and the private sector on science - based solutions.

«We know the endogenous cannabinoid system is very dynamic; it goes through changes over the life span,» says Ryan McLaughlin, a researcher who studies cannabis and stress at Washington State University and was not involved in the current work.

This is the first time anyone has examined regional climate change in the central United States by directly comparing the influence of greenhouse gas emissions to agriculture, says Nathan Mueller, an earth systems scientist at the University of California (UC), Irvine, who was not involved with this study.

Kansas State University researchers are involved in a study that found climate change is predicted to reduce big bluestem's growth and stature.

Essentially, «title washing» is a practice involving moving a vehicle to different states and changing ownership multiple times in an attempt to destroy any record of damage.

This will be an important approach for studying redox changes in disease states including cancer, neurodegenerative disorders, cardiovascular disease, sickle cell disease and many others which are known to involve oxidative stress.»

But exacting measurements of these properties — the so - called «equation of state» involved as matter changes from one phase to another in these collisions — have proven challenging.

Richard Alley, a Penn State geosciences professor who wasn't involved with the new study, said far more work is needed to understand the effects of wind and ocean changes in the Southern Hemisphere's most frigid stretches.

Changing such systems would involve changing entire legal frameworks in place in WesternChanging such systems would involve changing entire legal frameworks in place in Westernchanging entire legal frameworks in place in Western states.

But the rapid retreat seen in the past 40 years means that in the coming decades, sea - level rise will likely exceed this century's sea - level rise projections of 3 feet (90 centimeters) by 2100, issued by the Intergovernmental Panel on Climate Change (IPCC), said Sridhar Anandakrishnan, a glaciologist at Pennsylvania State University, who was not involved in the study.

If the plan is put into place, it would change the state's system for water delivery from the region, which currently involves pumping it from the delta itself in a practice that harms the fragile ecosystem and leaves farmers and residents with widely varying amounts of water from year to year.

«This type of work is great to understand what's changing and why,» says Hilary McMillan, a hydrologist at San Diego State University in California who was not involved with the study.

While attention has been focused on Trump's rhetoric, State Department envoys, federal agencies, and government scientists remain active participants in international efforts to both research and fight climate change, according to U.S. and foreign representatives involved in those efforts.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

The research conducted by Wright State University involved identifying and measuring size changes of motor neuron types in a mouse model of familial ALS.

The plan also states that China will be actively involved in the global effort to address climate change, including advancing its own contribution, and will deepen its bilateral dialogue with other countries.

One of the lessons when it comes to balancing postures is that balance is not a state or place to arrive at... it involves constant adjustment and attunement to the changing conditions of the moment, hence the oh so familiar wobbles we get in tree pose for example.

«The psychology employed by humans choosing a mate can definitely be environmentally sensitive and the nature of online dating is triggering changes in underlying preferences and decision behavior of those involved,» Mr. White stated in the study.

That's right, despite the fact that Cronenberg had previously stated that he had no desire to take part in a remake (he wasn't involved in The Fly II either), he has apparently had a change of heart.

You'll be better positioned to convince your state that you should be involved — but even if you don't take part in the state's plan, you've laid the groundwork for education change in your community.

• Evidence of aggregate declines in the performance of the special education students in a given district would lead to a state or federally led intervention involving supervised programmatic changes.

Indeed, other changes have involved shifts in power at the local level or even decentralization below the school district level, rather than greater control by the state (or the federal government).

At the Civil Rights Project, she is involved in a five - year study examining the implementation of the «No Child Left Behind Act» of 2001 and how this legislation influences educational change in states and local school districts.

As part of the state's Race to the Top grant, Tennessee implemented a number of school turnarounds, all of which involved a change in school leadership and a substantial turnover of teachers.

These involve recent LEA boundary changes that have not yet been incorporated into the Census database for LEAs (which usually takes two to three years), charter schools that are treated as separate LEAs under the laws of some states but are not in the Census LEA database (because they are not based on exclusive geographical boundaries), and some special purpose LEAs that provide particular educational services (such as vocational and technical education or education for certain students with disabilities) to multiple «regular» LEAs in certain states.

While many states have been working on changes to licensure structures and have been involved in data analysis regarding the teacher pipeline, one of UPTEP's new goals includes a focus on preparing all teachers to teach students with special needs, something not seen in other states.