Sentences with phrase «involve changing rates»

Not exact matches

For example, varying assessments of risks involved will change the capitalization and discount rates.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Feedback from more than 200 participants involved in the pilot has been overwhelmingly positive, with 94 % rating the resource as «excellent» or «good» and just under two thirds (65 %) intending to make a change to their school food culture as a result.

Given many changes in how infertility is treated today, SART is striving to help patients better understand what's involved in success rates.

The test results will still be used to measure teachers» performance ratings, and a spokesman for the teachers union says until that changes, many of the parents involved in the boycott movement will continue to opt their kids out of the tests.

The Cuomo administration, after hearing similar versions of that complaint from many involved in the program, is planning to change the rates.

Some of the bankers told Sunday Vanguard that some of the depositors now trade or invest their dollar cash with Bureau de Changes, BDCs, where exchange rates and returns on investments are far higher, not minding the risks involved.

Barry Sinervo, a reptile and ecology expert at the University of California, Santa Cruz, who was not involved with the recent study, pointed to some of his own research, such as a study published in Science in May 2010 that examined extinction rates in lizards alongside changing climatic conditions.

The research, funded by the Medical Research Council, involved creating the first global model of how mortality rates change with hot or cold weather.

By performing experiments in the precisely controlled environment of the CLOUD chamber, the project's scientists can change the concentrations of chemicals involved in nucleation and then measure the rate at which new particles are created with extreme precision.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

The results are preliminary, Haussler cautions, but he considers it «a tantalizing hypothesis» that HAR1 is involved in the changes that led to our bigger, more complex cortex.The comparison turned up 49 places where an accelerated rate of mutation stood out in the human genome.

Climate change involves an increase of aridity and evaporative rates.

«Tropical ecosystems suffered widespread devastation each time that greenhouse gases rose rapidly in the past, despite differences in the rates of change and species involved.

The new estimates are reasonable considering the rates of glacier change scientists are seeing at the moment, says Dr Ted Scambos, lead scientist at the National Snow and Ice Data Center, who wasn't involved in the study.

The more dynamic picture in the new simulations suggests that the rate of change in the first half of this century — which does not involve a significant contribution from processes like marine ice - cliff instability, or hydrofracturing — is essentially uncorrelated with the rate of change later in the century.

There are some various proposed mechanisms to explain this that involve the surface energy balance (e.g., less coupling between the ground temperature and lower air temperature over land because of less potential for evaporation), and also lapse rate differences over ocean and land (see Joshi et al 2008, Climate Dynamics), as well as vegetation or cloud changes.

Services rated poor involved issues where children had too many changes of social worker high caseloads, delays in undertaking visits and failure to see children alone.

However, the risks involved should be explained clearly in the financial plan, such as possible loss of capital, the instability of interest rates, repayments of the loan or unexpected life changes, such as redundancy.

Winner: Woodside Primary Academy, London Woodside was put into special measures by Ofsted in 2012, but changes made under headteacher Shane Tewes involved parents and pupils, and a remarkable turnaround now sees the school rated Outstanding.

Macroeconomics: Macroeconomics involves the behavior of the aggregate economy such as changes in national income, unemployment, gross domestic, rate of growth, and price levels.

Known as a «hybrid» loan, a 5/1 ARM involves a fixed interest rate for the first five years and a variable rate that changes every year thereafter.

While we're here to discuss your options in greater detail whenever you're ready, here's a quick look at the most common loan types, which primarily involve a fixed interest rate over a long period of time, or a rate that can change over time.

The possible changes include steps to prevent business owners from using their private corporations as a way to shift their income among family members subject to lower personal tax rates — even if those relatives are not involved in the business.

Two risks related to rate - reset preferreds involve call risk and changes in the regulatory landscape.

Generally speaking, loan repricings involve issuers reaching out to market participants via an arranger to lower the interest rate on an existing facility, with no other changes to the loan agreement.

On the other hand, if you ask the North Carolina Rate Bureau what happens, they'll tell you that it's a long, arduous process involving significant study of the impact of a rate change, whether the economy can handle the change in premiums, whether customers want to pay the new premiums, and many other factors and that the decision is made with painstaking cRate Bureau what happens, they'll tell you that it's a long, arduous process involving significant study of the impact of a rate change, whether the economy can handle the change in premiums, whether customers want to pay the new premiums, and many other factors and that the decision is made with painstaking crate change, whether the economy can handle the change in premiums, whether customers want to pay the new premiums, and many other factors and that the decision is made with painstaking care.

You may qualify to have your mortgage terms changed (modified); this could involve lowering your mortgage rate and or extending your repayment term.

A longer - term bond usually involves more risk that the borrower will default, or interest rates will change, or the lender will find a better potential use for their money.

The reasons for those higher rates involve everything from extraordinary fiscal stimulus via trillion dollar deficit spending, significant changes to the tax structure, an increase in Treasury bond supply, central bank quantitative tightening (QT), a decrease in Treasury bond demand from other countries as well as inflationary pressures.

Are there annual fees involved and what is the interest rate change after an introductory period?

A more sophisticated interest rate anticipation strategy might involve the use of «zero coupon» or «strip» bonds, which are far more sensitive to interest rate changes than normal bonds.

Changes from the previous edition include updates for changed tax rates, new IRS interpretations of certain rules involving rollovers and conversions, and expanded availability of in - plan Roth conversions.

Loan modification involves negotiating with your mortgage lender for changes to the rates and terms on your mortgage loan that make it more affordable to you.

The value of these securities may be significantly affected by changes in interest rates, the market's perception of issuers, and the creditworthiness of the parties involved.

REIT funds may be subject to other risks including, but not limited to, changes in real estate values or economic conditions, credit risk and interest rate fluctuations and changes in the value of the underlying property owned by the trust and defaults by borrowers.In addition to normal risks associated with equity investing, international investing may involve risk of capital loss from unfavorable fluctuations in currency values, from differences in generally accepted accounting principles, and from adverse political, social and economic instability in other nations.

Practically speaking, that means that unless and until governments get involved and start making changes to the rules (which I don't think anyone really wants), game rating agencies aren't going to get involved.

Temperature tends to respond so that, depending on optical properties, LW emission will tend to reduce the vertical differential heating by cooling warmer parts more than cooler parts (for the surface and atmosphere); also (not significant within the atmosphere and ocean in general, but significant at the interface betwen the surface and the air, and also significant (in part due to the small heat fluxes involved, viscosity in the crust and somewhat in the mantle (where there are thick boundary layers with superadiabatic lapse rates) and thermal conductivity of the core) in parts of the Earth's interior) temperature changes will cause conduction / diffusion of heat that partly balances the differential heating.

[Response: Your quote stated exactly that the equation for determining T of the planet involved an equation using the rate of change of the heat content, the forcing and lambda.

The findings are «interesting», but could hold «limited relevance» to understanding future climate change, which is occuring at a much faster rate than the warming observed from the LGM to the Holocene, says Prof Amanda Maycock, a research fellow from the University of Leeds who was not involved in the new study.

I do, however, recognize the point of your suggestion that year to year fluctuations in the rate of CO2 change can involve flux changes between atmospheric and terrestrial or oceanic sources that add to or subtract from the human contribution.

Disputes within climate science concern the nature and magnitude of feedback processes involving clouds and water vapor, uncertainties about the rate at which the oceans take up heat and carbon dioxide, the effects of air pollution, and the nature and importance of climate change effects such as rising sea level, increasing acidity of the ocean, and the incidence of weather hazards such as floods, droughts, storms, and heat waves.

Scenarios devised by the Intergovernmental Panel on Climate Change don't just involve different estimations of climate sensitivity, they involve different projections of the spread of renewable energy and efficiency, the development of carbon capture and sequestration (CCS), the rate of deforestation, and all sorts of other social, political, and technological trends.

Now we have a correlation between economic cycles and rates of change in Length of Day Lunar cycles (sunspots involved too!

Accepting that population will continue to grow, choices will involve changes in technology and human behaviour, so that the production and use of products and services is associated with lower rates of GHG emissions, and consumers choose products, services, and activities with lower ‐ unit GHG emissions.

The United Nations» Intergovernmental Panel on Climate Change, a global effort involving hundreds of climate scientists and the governments of 100 nations, projected in 2001 that, depending on the rate of greenhouse gas emissions and general climate sensitivities, the global average temperature would rise 2.5 to 10.4 degrees Fahrenheit between 1990 and 2100.

It is very probable that the impact was negligible, because I have significantly overstated the number of papers involved, because not all papers involved were rated as endorsing the concensus, and because even of those endorsing the concensus, there is a high probability that the rating would not have changed to neutral, or not endorsing the consensus without the discussion.

The circulation changes alter all the processes involved in the rate of energy transfer from surface to space.

The more dynamic picture in the new simulations suggests that the rate of change in the first half of this century — which does not involve a significant contribution from processes like marine ice - cliff instability, or hydrofracturing — is essentially uncorrelated with the rate of change later in the century.