Sentences with phrase «involved in gene expression»

Key proteins involved in gene expression depend on each other when forming a heart in an embryo, but, if left alone, they start to run amok

For instance, protein and DNA modifications involved in gene expression in kidneys must at some point be turned off.

The theory holds that histone proteins, which combine with DNA to form chromosomes, are more intimately involved in gene expression than their general role of facilitating or hindering gene activation suggests.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Not exact matches

The DNA segments that carry genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the expression of genetic information.

Messenger RNA (mRNA) serves as an important intermediary during gene expression, by relating the genetic information of DNA to the molecular mechanisms involved in manufacturing proteins.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

Traditional strain - selection techniques are supplemented with strain screening, which can involve examining gene - expression patterns through PCR or understanding global gene expression in relation to environmental factors using gene chips.

To identify genes involved in the patterning of adult structures, Gal4 - UAS (upstream activating site) technology was used to visualize patterns of gene expression directly in living flies.

Sure enough, plant root cells that harbor fungal arbuscules increase their expression of genes involved in producing such lipids by 3000-fold.

They did this by testing tissue concentrations of fatty acids in liver, muscle and brain tissue, along with the expression of genes involved in regulating EPA status and its physiological benefits.

Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in abnormal facial cartilage, smaller eyes and structural abnormalities of neurons involved in the development of reproductive organs.

The researchers also looked at the expression of a gene involved in the control of wing development, and found similarity between the lab - induced supersoldiers and the natural ones.

«Our discovery about the ROC40 protein suggests that it may be increasing the expression of genes involved in the synthesis of oil in microalgae,» Rathinasabapathi said.

This information could help researchers develop ways to restore the expression of more genes involved in hair growth and to increase the efficiency of the induction.

«Rapamycin affected the expression of genes involved in calcium regulation, mitochondrial metabolism, hypertrophy and inflammation,» said Melov.

«We also found that reduced cohesin led to changes in the expression of genes involved in nerve cell development and the response to an immune signaling protein,» corresponding author Toshihide Yamashita says.

Among these is a substance, called EZH2, that affects the expression of a wide variety of genes, including those involved in cell development and differentiation.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

DNA methylation, one mechanism of epigenetics, is a chemical tag on DNA that does not change the gene sequence but is involved in controlling gene expression.

It involves detecting micro-RNAs (miRNAs): small, non-coding RNA molecules that are important in the regulation of gene expression.

«Genes code for the sequence of amino acids in proteins, and some are involved in the regulation of the expression of other genes,» he Genes code for the sequence of amino acids in proteins, and some are involved in the regulation of the expression of other genes,» he genes,» he says.

The researchers concluded that IL - 17A is the dominant cytokine involved in the expression of psoriasis - related genes.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

When Bordenstein and Brucker compared gene expression patterns in normal and microbe - free offspring, they found significant changes in many of the genes involved in the immune response (Science, doi.org/m87).

In addition, the team examined the relationship between sleep and the expression of a gene in the feather follicles involved in producing dark, melanic feather spotIn addition, the team examined the relationship between sleep and the expression of a gene in the feather follicles involved in producing dark, melanic feather spotin the feather follicles involved in producing dark, melanic feather spotin producing dark, melanic feather spots.

Right now, the UPV / EHU researchers are in the phase involving the validation of candidate genes by analyzing their expression levels in biopsies of melanoma and nevi (growths of non-malignant melanocytes).

«It also affected the expression of certain genes in the brain that are involved in «neuroplasticity», which may be associated with memory impairment,» says Morris.

Ma and colleagues first discovered that mitochondria was involved in SMA when they analyzed gene expression profiles of motor neurons from SMA and control mice.

For instance, a tumor influences the expression of genes in immune system cells that are involved in the body's response to cancer.

Basically, the gene makes a molecule involved in preparing other genes for expression, helping to distinguish between regions of genes that should be manufactured and those that are silent genetic filler.

Rather than listing specific genes that manifest themselves differently, or are differentially expressed, between queens and workers, the team looked for genes with similar expression patterns across samples that may be involved in maintaining the structural, behavioural and functional differences observed between queens and workers.

More recently, some small RNAs have been found to be involved in regulating gene expression.

The study used novel gene expression methods that allowed the researchers to identify over one thousand genes that are involved in the regeneration process of individual stentor cells.

He has been studying differences in gene expression in infected and uninfected plants and finds that the fungus seems to increase the activity of genes involved in seed production.

Finally, the researchers showed in tests with mice that their nanoparticle iNOP - 7DS can be delivered effectively to the liver, spleen, and lung; and it suppressed the level of messenger RNA involved in the expression of the ApoB gene.

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

Genes involved in microcephaly, a condition in which patients have brains roughly the size of chimpanzee brains, directly control the levels of BRCA1 expression, he says.

In particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferatioIn particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferatioin turn regulates a large number of genes involved in cell proliferatioin cell proliferation.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

Several research groups are pursuing gene therapy approaches to regenerate skin, such as using genes to control expression of growth factors involved in skin healing.

That would be a way to influence the expression of many genes involved in the proliferation of cancer cells.»

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

To determine whether shifts in the balance of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently at Sharpe's lab (CRG), and his colleagues carefully compared the expression, function and regulation of genes involved in anterior - posterior patterning in pectoral fins of catsharks, with those of mice.

University of Alabama at Birmingham researchers show, for the first time, that the well - known mechanism of gene expression control — dynamic changes in DNA methylation — is also involved in changes to the excitability of neural cells.

The virus essentially acts like a «sponge», preventing MSI1 from working correctly and altering the expression of many genes involved in neuronal development.

Mao's study examined mitochondria - associated gene expression in the mouse eye tissue and found significant changes in several genes involved in oxidative stress response.

The second group, headed by John Mattick, a molecular biologist at University of Queensland, St. Lucia, in Australia, identified a new class of short RNAs that also seem to be involved in regulating gene expression, though their function needs to be confirmed.

They found that genes involved in this process become poised for expression but remain inactive until the correct combination of molecules is provided.

To see what genes might be involved in this increased aggression, the team used microarrays to look for differences in gene expression in fly brains.