Sentences with phrase «involved in the disease»

New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of genes involved in the disease.

«This paper offers a significant advance in mapping genes involved in disease.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Even if this technique proves too invasive for routine use, it may inspire new, more precise drugs that affect only the neurons involved in a disease.

As a courtesy, Vogelstein, whose lab had already uncovered a fistful of genes involved in the disease, offered to test the 39 - year - old man for known mutations.

Already, Surani's and Hanna's groups have used the artificial PGCs to investigate the role of individual enzymes in epigenetic regulation, which may one day show how the epigenetic networks are involved in disease.

Changes in motor neurons are involved in disease onset, but disease progression seems to be dictated by changes to astrocytes, microglia and oligodendrocytes.

But recent studies in both humans and lab mice have suggested that motor neurons in the brain — the upper motor neurons — may be involved in disease progression, although the extent and significance of this involvement has remained unknown.

This animation guides us through the immune pathways involved in the disease, from the first signs of self - reactive immune cells to joint damage and other symptoms.This article was reproduced with permission and was first published on January 25, 2016.

The main focus of their research was to identify causative mechanisms involved in the disease.

Show how analysis of CSF samples from Alzheimer's disease patients has identified potential new biomarkers and provided new information about some of the major pathways involved in the disease

For the study, Ho and Kosik, leading experts in Alzheimer's research, compiled a list of 64 conceivable approaches to drug discovery, addressing a range of biological mechanisms that may be involved in the disease.

Phevor works by using algorithms that combine the probabilities of gene mutations being involved in a disease with databases of phenotypes, or the physical manifestation of a disease, and information on gene functions.

In an ideal world, academic scientists identify targets for drugs — typically proteins involved in disease — and industry scientists look for agents that interfere with those targets» function.

This suggests that problems with mitophagy may be involved in those diseases.»

New work in mice finds that testosterone impacts immune cells involved in the disease.

They confirmed the location for one fungal gene involved in the disease, AVRHt1, and found a candidate location for another, AVRHt2.

He says he hopes that the «new view» that environmental factors can trigger or deter genetic changes involved in the disease will help remove some of the disorder's stigma.

The researchers note that elevated IL - 6 is observed in many different inflammatory diseases (perhaps as the body's attempt to protect itself), and macrophages are often crucially involved in disease pathogenesis.

A year ago we started thinking, why don't we select a single family with an interesting disease and see whether studying a smaller group of related individuals makes it possible to identify the genes involved in that disease.

The study of these models shows that proteins MCL1 and GlialCAM play a crucial role in localization and regulation of chloride channel CLC - 2 in the glia, and proves that the channel is involved in the disease.

Until now, however, nobody has found any evidence that apoptosis is involved in diseases caused by more complex parasitic organisms.

TSC will be collecting random data, he explains, while half of the government - funded investigators will be focusing on specific genes involved in disease.

This approach could now be adopted for developing treatments for other conditions, by generating DNA sequences that target specific microRNAs involved in diseases, he says.

The strategy of drug discovery may correct defects associated with genetic diseases as it continued to I - Stem is based on the access that pluripotent stem cells provide molecular mechanisms involved in these diseases.

If BIN1 is found to be involved in disease pathogenesis, it will advance efforts towards targeting BIN1 as a potential strategy for disease modification.

In some cases, alternative splicing of RNA results in the production of proteins that are involved in disease.

The workshop aimed to enable an exchange of experience on the opportunities and challenges that Next Generation Sequencing (NGS) poses in the daily operations of the Swedish health care, authorities involved in disease control, as -LSB-...]

Research in the lab of Edward P. Feener, Ph.D., Investigator in the Section on Vascular Cell Biology and Director of the Proteomics Core at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, now has shown that a substantial percentage of patients with DME do not have high levels of VEGF in the fluid inside their eyes but do have high levels of a protein called PKal (plasma kallikrein) and associated molecules that are key players in an inflammatory molecular pathway involved in the disease.

Likewise, our laboratory also studies models of Alzheimer's, ALS, and «mad cow» diseases, where proteins involved in these diseases aggregate inside axons.

The tool allows for the prioritization of single nucleotide variants to identify those that are likely to be involved in disease.

By targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the disease.

Other cellular structures, including some involved in disease, are also organized by phase separation.

Not only is vitamin D involved in disease prevention, but it can be very effective in alleviating some of their symptoms.

Some scientists suspect hormones — the body's chemical messengers — may be involved in the disease process in some way.

In the midst of all of our health battles, and all the research I've done, I've read a lot about how parasites are actively involved in disease.

I would try and find a more holistic oriented veterinarian when the time is right for your next pet who often looks at all of the factors involved in disease from the environment, to diet, to overuse of drugs and / o vaccinations.

Many different types of symptoms can be involved in this disease, and are wholly dependent on which organs are affected by tumor growth.

Since then, much has been done to understand the processes involved in this disease and in the treatment of DM The age at onset is 5 to 14 years.

Cats have two thyroid glands, and in most cases (more than 70 %) both are involved in the disease, and become enlarged (a change called «nodular hyperplasia», which resembles a very benign tumour).

Because of the potential heritable components involved in this disease, dogs that have suffered generalized demodicosis should not be bred.

However, while dental plaque and some calculus may be present, the amount of inflammation is quite disproportionate and it is thought that some immune dysregulation is involved in the disease where the cat's immune system may be responding too aggressively to the presence of bacteria or other infectious agents in the mouth.

These conditions have a component of inflammation involved in the disease process, and omega - 3 fatty acids from fish oil can help reduce inflammation associated with these conditions.

When paralysis is present the most likely areas of the brain to be affected are the brain stem, but the cervical spinal cord can also sometimes be involved in the disease process.

Detection of any emerging feline viruses involved in the disease will help inform future vaccinations strategies and biosecurity guidelines to protect and reduce fatalities in cats worldwide.

Demonstrated track record identifying protein targets involved in the disease process and developing small molecules that inhibit their functional activity.

Not exact matches

The treatment (which involves injecting people with modified viruses carrying the CRISPR technology that will go in and repair the faulty DNA) can be injected directly into the retina and, in this case, used to delete the portion of the CEP290 gene that's responsible for the disease.

Gene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes disease.

More than 33,000 American deaths involved opioids in 2015, according to the Centers for Disease Control (CDC), and opioid overdoses have quadrupled since 1999.

«We got involved in biotech in the late 90's when two of our children were diagnosed with a rare genetic disease... at the time there was nothing,» said Crowley «So we really focused as parents initially on what could we do to help drive science to a cure.