Not exact matches
In the meantime, the MUSC team, led by Yu, will continue their work and try to extend the current findings by investigating how other miRs may be
involved in regulating T - and B - cell function during
allogeneic BMT.
Rejection by CD8 + T cells does not appear to
involve either allospecific CTL or DTH effector mechanisms; however, CD8 + T cells are able to induce significant apoptosis of
allogeneic corneal endothelial cells.
Dr. Goodman is also
involved in collaborative efforts with the San Antonio Bone Marrow Transplant Center to study the outcome of
allogeneic bone marrow transplants following a relapse from autologous bone marrow transplants.
Allogeneic cell therapies
involving primary cell types such as bone marrow mesenchymal stromal / stem cells (BM - MSCs), hematopoietic stem and progenitor cells (HSPCs), and T and natural killer (NK) cells for immunotherapy applications are especially challenging because of the vigorous process of screening...
Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment
involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or
allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.