Sentences with phrase «involving changes in the number»

Not exact matches

Certain matters discussed in this news release are forward - looking statements that involve a number of risks and uncertainties including, but not limited to, doubts about the Company's ability to continue as a going concern, the need to obtain additional funding, risks in product development plans and schedules, rapid technological change, changes and delays in product approval and introduction, customer acceptance of new products, the impact of competitive products and pricing, market acceptance, the lengthy sales cycle, proprietary rights of the Company and its competitors, risk of operations in Israel, government regulations, dependence on third parties to manufacture products, general economic conditions and other risk factors detailed in the Company's filings with the United States Securities and Exchange Commission.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These statements may involve a number of risks, uncertainties and other factors that could cause actual results to differ materially, including the performance of financial markets, the investment performance of NexPoint Advisors, L.P.'s or Highland Capital Management L.P.'s sponsored investment products, general economic conditions, future acquisitions, competitive conditions and government regulations, including changes in tax laws.

People, I believe, can change for the better by the number of people involved (strength in numbers).

What is decisive in the present connection, however, is that the number of such cases has increased in a way that we might almost say involved a change of kind.

For instance, one admits that in much of evolution (probably all above the bacteria), evolutionary changes involve enormous numbers of genes, rather than a selection of one or two particular genes (although that occurs in a few instances, possibly, for instance, in industrial melanism).

There will most likely be changes to the countries involved in the movement and it is hoped that the number of countries continues to grow.

The players, the supporters and everyone that is involved in one way or another with Everton is well aware of just how frustrating this season was and Roberto Martinez announced that a number of changes will be done in order to not go through another underwhelming season.

All of us involved in youth sports - from parents, to coaches, from athletic trainers to school athletic directors to the athletes themselves - have a responsibility to do what we can to make contact and collision sports safer, whether it by reducing the number of hits to the head a player receives over the course of a season (such as N.F.L. and the Ivy League are doing in limiting full - contact practices, and the Sports Legacy Institute recently proposed be considered at the youth and high school level in its Hit Count program), teaching football players how to tackle without using their head (as former pro football player Bobby Hosea has long advocated), changing the rules (as the governing body for high school hockey in Minnesota did in the aftermath of the Jack Jablonski injury or USA Hockey did in banning body checks at the Pee Wee level), or giving serious consideration to whether athletes below a certain age should be playing tackle football at all (as the American Academy of Pediatrics recommend).

They found that one month after training, the children showed increased activation in the intraparietal sulcus and reduced neural activation elsewhere in the parietal lobes — a hint that their improvements in arithmetic were related to changes involving brain areas that respond to number.

Adds Harold Brooks, senior scientist at NOAA's National Severe Storms Laboratory, who was not involved with this project, «The study is important because it addresses one of the hypotheses that has been raised to explain the observed change in number of tornadoes in outbreaks.

So far, the researchers have succeeded in calculating with two - digit numbers using two photonic phase - change cells, but the extension to large multi-digit numbers simply involves the use of more cells.

In one of the most anticipated events in the mental health field, the American Psychiatric Association will release the latest version of its Diagnostic and Statistical Manual of Mental Disorders (DSM - 5) next month, involving changes to a number of categories and diagnoseIn one of the most anticipated events in the mental health field, the American Psychiatric Association will release the latest version of its Diagnostic and Statistical Manual of Mental Disorders (DSM - 5) next month, involving changes to a number of categories and diagnosein the mental health field, the American Psychiatric Association will release the latest version of its Diagnostic and Statistical Manual of Mental Disorders (DSM - 5) next month, involving changes to a number of categories and diagnoses.

The researchers looked at more than 800 U.S. cases involving climate change or coal - fired power plants between 1990 and 2016, and found a dramatic rise in both the number of climate cases and the proportion that relied on scientific evidence, according to first author Sabrina McCormick, a sociologist at George Washington University in Washington.

According to Puzas, teriparatide significantly speeds up fracture healing by changing the behavior and number of the cartilage and the bone stem cells involved in the process.

Mapping the changes in copy number to the phylogeny of these Y chromosomes previously established by the Project identified at least 20 mutational events, and investigation of flanking paralogous sequence variants showed that the mutations involved flanking sequences in 18 of these, and could extend over > 30 kb of DNA.

The 5 -3-2 plan works so well because it uses a form of periodization in your training, involving a change of weight and number of reps over a period of time, which results in gaining muscle mass and strength.

In a study involving dietary ketosis via a low carbohydrate diet (less than 10 percent of total calories), compared to subjects on a 50 percent carbohydrate diet, the low - carbohydrate subjects demonstrated better performance on memory tests, with higher scores being correlated to higher serum KB levels.14 A study using cultured mouse hippocampal cells showed that addition of the KB β - hydroxybutyrate (β - OHB) to cells exposed to Aβ resulted in no decrease in the numbers of dendrites or total neurons — two of the noted pathological changes in AIn a study involving dietary ketosis via a low carbohydrate diet (less than 10 percent of total calories), compared to subjects on a 50 percent carbohydrate diet, the low - carbohydrate subjects demonstrated better performance on memory tests, with higher scores being correlated to higher serum KB levels.14 A study using cultured mouse hippocampal cells showed that addition of the KB β - hydroxybutyrate (β - OHB) to cells exposed to Aβ resulted in no decrease in the numbers of dendrites or total neurons — two of the noted pathological changes in Ain no decrease in the numbers of dendrites or total neurons — two of the noted pathological changes in Ain the numbers of dendrites or total neurons — two of the noted pathological changes in Ain AD.

The basic principles of strength training involve a number of repetitions (reps), sets, tempo, exercises and force to cause desired changes in strength, endurance, size or shape by overloading of a group of muscles.

Many family farmers say the rule changes — a response to a number of high - profile farming accidents involving kids around the country — are well - intended but could put some businesses in a bind.

Worksheet involves: - collecting data from class - creating tally charts from data - drawing bar charts from data (as worksheet progresses, pupils have to add more information onto the bar chart themselves)- finding the mode - creating a question for others to answer based on their data To edit the chart sections to change class name or numbers, double - click in the chart area.

Find the reciprocal of a number given as a fraction or decimal · Use index laws to calculate with squares and cubes · Use index laws to simplify and calculate the value of numerical expressions involving multiplication and division of integer powers, and powers of a power · Find the prime factor decomposition of positive integers and write in index form · Know the effects that a change of place value has on a calculation · Multiply and divide by any number between 0 and 1 · Multiply and divide decimal numbers by whole numbers and decimal numbers (up to 2 d.p.), eg 266.22 ¸ 0.34 · Use brackets and the hierarchy of operations (BIDMAS) · Use index notation for integer powers of 10 · Add, subtract any numbers including negative decimals · Check answers by inverse calculation · Find the common factors and common multiples of two small numbers

As part of the state's Race to the Top grant, Tennessee implemented a number of school turnarounds, all of which involved a change in school leadership and a substantial turnover of teachers.

Armed law enforcement officers are not educators, social workers, or counselors, and overwhelming evidence shows that when schools involve law enforcement in minor, non-violent behavioral infractions, students of color are disproportionately impacted.1 In our 2015 policy paper, Climate Change: Creating Safe, Supportive Schools for All Students, E4E - New York members pointed out that there are more police officers than school counselors in New York City schools and called on the NYC Department of Education to turn this shameful number on its head by increasing the amount of school counselorin minor, non-violent behavioral infractions, students of color are disproportionately impacted.1 In our 2015 policy paper, Climate Change: Creating Safe, Supportive Schools for All Students, E4E - New York members pointed out that there are more police officers than school counselors in New York City schools and called on the NYC Department of Education to turn this shameful number on its head by increasing the amount of school counselorIn our 2015 policy paper, Climate Change: Creating Safe, Supportive Schools for All Students, E4E - New York members pointed out that there are more police officers than school counselors in New York City schools and called on the NYC Department of Education to turn this shameful number on its head by increasing the amount of school counselorin New York City schools and called on the NYC Department of Education to turn this shameful number on its head by increasing the amount of school counselors.

«It wasn't necessarily greeted warmly by everyone involved, but you didn't need a court case or legislative change to change practice, and I think that's true in a number of places.»

Because a small number of borrowers account for the majority of dollars in default, changes targeted at a small number of individuals and institutions could have large implications for taxpayers and the students involved, helping to keep borrowing to levels borrowers can realistically repay and to reduce costs of these programs for taxpayers.

Unlike primary market transactions, trades in the secondary market normally do not involve the issuer of the instruments or change the number of instruments outstanding.

In most cases high numbers of yeast are involved causing the color change.

Animal Welfare groups and volunteers are attempting to change that point of view by educating owners and potential owners about the lifelong commitment involved in adopting an animal, how to be a responsible pet owner, about the large number of adoptable animals available at shelters, and about the often poor condition of pet shop pets.

Credit Card and Social Security numbers were not involved in the relatively minor breach, which revolved around the website for the game Neverwinter Nights, but if you've ever registered on that site, you may want to change you passwords just to be safe.

I am not sure I understand Andy's question number (5), but «nature» involves many species: even if some parts of «nature» may survive global warming at the end (as parts of it have survived natural climate change events in the past), many parts of it are already going extinct and we are to blame this time around.

Establishing direct links between climate change and migration, «like skyrocketing asylum applications and temperature,» can be difficult because of the vast number of variables involved, Newsweek concedes, while pointing to «the influence of drought in the years - long Syrian conflict, New Zealand's recent proposal to create a visa category for climate refugees and the United Nations» recent recognition that climate change can contribute to displacement within countries and internationally.»

Hundreds: the number of scientists involved in writing the assessments of climate science by the National Research Council of the National Academies, the Intergovernmental Panel on Climate Change, and the U.S. Global Change Research Program.

In 2004, the International Broadcasting Trust - a lobby group funded by a number of charities, including many involved in campaigning on climate change - devised the first in a series of seminars on development issues, where the lobbyists could address broadcasterIn 2004, the International Broadcasting Trust - a lobby group funded by a number of charities, including many involved in campaigning on climate change - devised the first in a series of seminars on development issues, where the lobbyists could address broadcasterin campaigning on climate change - devised the first in a series of seminars on development issues, where the lobbyists could address broadcasterin a series of seminars on development issues, where the lobbyists could address broadcasters.

A number of the involved firms — refineries, storage companies, etc — are in line to get massive tax breaks related to changes to their facilities to handle the tar sands.

This extends well beyond the CRU itself — most of the e-mails were exchanged with researchers in a number of other international institutions who are also involved in the formulation of the IPCC's conclusions on climate change.

Because of the small number of species involved in small areas over different studies, Kharouba's team could not find a statistically significant link between temperature and changes in how species sync together.

For example, in the forthcoming U.K. Climate Impacts Program (UKCIP08) scenarios that Lenny refers to (and in which I'm involved), we plan to supply information on changes in a number of climate variables, at a range of space and time scales, for different periods during the twenty - first century.

In recent years she has been involved in a number of high - profile multi-party trade union and TUPE disputes as well as advising and acting on cross-border service provision changeIn recent years she has been involved in a number of high - profile multi-party trade union and TUPE disputes as well as advising and acting on cross-border service provision changein a number of high - profile multi-party trade union and TUPE disputes as well as advising and acting on cross-border service provision changes.

Working in the City of London and Aberdeen, he acts for management teams, banks and institutions and has been involved in a number of large scale overseas transactions in the development of game - changing new technology in the oil and gas industry.

A study from the University of Arizona investigated whether the parenting coordinator is potentially effective in easing the burden on the judges, court personnel, and outside agencies that become involved with families in these cases and to test whether the parenting coordinator is potentially effective in assisting high - conflict parents to reduce the number of motions and changes made in each case for a 2 - year period.

As a result of these changes a number of group recipients were advised that pursuant to s. 183 NTA their funding will be terminated unless they are directly involved as a party or future party in proceedings relating to particular native title applications.

Good intentioned as those public servants proposing these changes may be, most professionals involved in the assessment and appeal process (including every assessor the author has queried) agree that the recommended changes will have a negative impact on the quality of assessments, and will ultimately increase both the number of appeals and the average time required to resolve an appeal.