Sentences with phrase «involving numerous changes»

Cancer is a complex disease involving numerous changes in cell physiology including the metabolic process on how it may be fed.

Not exact matches

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

«These results suggest that phytoestrogens can interfere with the normal estrogen feedback mechanisms with respect to release of gonadotropin in the ewe... although most studies into the effects of phytoestrogens have concentrated on changes in the reproductive tract, there are indications that they interfere with the hormone balance between the ovaries and the hypothalamo - adenohypophysical system... ewes on phytoestrogens have shown follicular abnormalities such as numerous small follicles, deficient antrum formation and signs of early atresia... it is possible that the permanent changes brought about by phytoestrogens in the brain are a result of these compounds interacting with estrogen receptors in this tissue, and subsequently influencing the re-synthesis or replenishment of cyto - plasmic estrogen receptors... phytoestrogens can interfere with the delicate feedback mechanisms involved in the release of the gonadotrophins.»

When considering the numerous factors that are involved with school change such as numerous stakeholders, new processes, and even the removal of ineffective teachers, it is reasonable to expect some amount of resistance from teachers, parents, and even community members.

If, for instance, you hire me to proofread your manuscript before publication and I find there are numerous grammar and usage errors, I will stop and contact you with a sample of your manuscript showing my findings, and we can then discuss perhaps copyediting instead, which would result in a change in fee and the time involved.

This collection of essays, which emerged from a 2012 conference of the same name at University of Wisconsin - Milwaukee's Center for 21st Century Studies, assembles texts by a group of scholars who expand on numerous challenges involving engagement with the nonhuman, such as climate change, biotechnology, genocide, terrorism, and war.

Numerous denier arguments involving slight fluctuations in the global distribution of warmer vs cooler sea surface areas as supposed explanations of climate change neglect all the energy that goes into ocean heat content, melting large ice deposits and so forth.

EPA is only one of numerous U.S. government agencies that conduct and support research related to climate change and is not designed to conduct, on its own, the vast body of scientific research that is reviewed in the IPCC Assessments, nor to carry out the massive assessment process embodied in the IPCC reports, which involves hundreds of authors and reviewers who make up most of the leadership of the international climate research community.

As we have documented in numerous articles on the disinformation campaign on this website, although responsible scientific skepticism is necessary for science to advance, the climate change disinformation campaign has been involved not in the pursuit of responsible scientific skepticism but in tactics that are morally reprehensible including: (a) telling lies about mainstream climate scientific evidence or engaging in reckless disregard for the truth, (b) focusing on unknowns about climate science while ignoring settled climate change science, that is cherry - picking the evidence, (c) creating front groups and Astroturf groups that hide the real parties in interest behind claims, (d) making specious claims about «good science», (e) manufacturing science sounding claims about climate change by holding conferences in which claims are made and documents are released that have not been subjected to scientific peer - review, and (d) cyber bullying journalists and scientists.

Arbitrated numerous contract / construction - related matters involving allegations of work defects, design defects, unauthorized change orders, delays, and breach of contract

I have successfully handled numerous high value claims, particularly in the accident at work field, involving serious, life - changing injuries.

Member of panel in numerous contract / construction - related matters involving allegations of work defects, design defects, unauthorized change orders, delays, and breach of contract

Since it is also critical to assure legal compliance during the background screening process due to the numerous laws involved, HR technology should provide all necessary disclosures, acknowledgments, and consents while automatically updating — in real - time — when Federal or state requirements change.

«The on - going changes to the numerous real estate laws and regulations, and refinements in the law driven by court decisions, impact everyone who may be involved in providing any type of professional services to the public.»