Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5 -
iodothyronine deiodinase in rat brown adipose tissue.
Thyroid hormone metabolism is impaired without selenium because iodine - based enzymes, called
iodothyronine deiodinases, can not be synthesized.
[28]
Iodothyronine deiodinases exist in several forms and are not yet fully understood, but do seem to play a role in preventing hypothyroidism.
(3 - 4)(11 - 12) There are at least 30 selenium dependent proteins, including the glutathione peroxidase enzyme, and
the Iodothyronine deiodinases enzyme (this is the one that converts thyroxine (T4) to bioactive (T3).