Sentences with phrase «ion channel as»

The naked mole rat version of TrkA failed to activate the ion channel as efficiently as the rat version of TrkA, Lewin and his colleagues reveal today in Cell Reports.

Deleting the drunkenness gene eliminated the associated ion channel as well.

Hydras have the same types of opsins and ion channels as we do.

Subthreshold ion channels as targets of neuromodulators and pharmacolocically active compounds

Not exact matches

Unlike the existing reverse - osmosis membranes responsible for more than half of the world's current water desalination capacity, the new membrane process dehydrates ions as they pass through the membrane channels and removes only select ions, rather than indiscriminately removing all ions.

These findings demonstrate that the ability of the channel to adapt its structure differently to K + and Na + is a fundamental aspect of ion selectivity, as is the ability of multiple K + ions to compete effectively with Na + for the conductive filter.

If the three - dimensional structures of the herb elements are elucidated, and a database of them can be established, it may facilitate computer - assisted imitation of docking between the herb element and physiologically important cell membrane proteins such as receptors, ion channels, and transporters.

«Monobodies are refined and powerful enough to attack important questions in biology and medicine, such as the structure of the fluoride ion channel, but they can also be used to generate molecules that are almost immediately useful in industry.

A team of researchers at Columbia Engineering has used miniaturized electronics to measure the activity of individual ion - channel proteins with temporal resolution as fine as one microsecond, producing the fastest recordings of single ion channels ever performed.

Monobodies were engineered to function as «crystallization chaperones» that stabilized and aligned fluoride ion channels so their structure could be determined.

Living systems achieve this functionality with their own version of electronics based on lipid membranes and ion channels and pumps, which act as a kind of «biological transistor.»

«Small molecules are perhaps more affordable as treatments and can hit things like this ion channel switch, TRPM7,» said researcher Michael Schappe, a graduate student in Desai's lab.

Since neurons can be depolarized by calcium and other positively charged ions, such as those the TRPV1 channel controls, we hope that this system may be effective at regulating neural activity.»

What's more, the ions don't dawdle as they march single file through the filter: as each potassium ion enters, its charge repels the ion ahead, pushing it out the channel.

But when they acutely (in seconds) added the potentiator VX - 770, the corrected CFTR protein exhibited a brief increase in function that rapidly waned, a sign that the corrected CFTR protein was losing its ability to function as an ion channel.

Alcohol modulates the switch, technically known as an ion channel, causing it to open more frequently.

On the basis of this selective permeability, ion channels are classified as potassium channels, sodium channels, etc..

Future studies will focus on using these nanobowls to deliver anle138b to the brain, as well as other diseased tissues and organs affected by toxic amyloid - beta ion channels.

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

New research has identified new molecules that could help in the fight to prevent diseases caused by faulty ion channels, such as cystic fibrosis.

Each neuron type is modeled as hundreds of interacting electrical «compartments;» which is an approximation to simulating the millions of ion channels in a neuron.

Researchers have known for decades that some microorganisms, such as single - celled green algae, have proteins that respond to light by opening a channel in the microbe's membranes, allowing the passage of electrically charged ions (such as calcium and sodium).

The receptor or ion channel, called TRPV1, was originally discovered in sensory neurons, where it acts as a sentinel for heat, acidity and spicy chemicals in the environment.

The therapy employs a virus to insert a gene for a common ion channel into normally blind cells of the retina that survive after the light - responsive rod and cone photoreceptor cells die as a result of diseases such as retinitis pigmentosa.

As soon as these cells are exposed to light, the channels open and positively charged ions flow into the muscle cell, which then contractAs soon as these cells are exposed to light, the channels open and positively charged ions flow into the muscle cell, which then contractas these cells are exposed to light, the channels open and positively charged ions flow into the muscle cell, which then contracts.

TRPV4 is an ion channel, a gateway in the cell membrane that rapidly lets in positively charged ions such as calcium and sodium.

In those organs, ion channels in the cell membrane of sensory nerve fibers expand as temperature increases.

In ICP, a liquid with charged and neutral ions, such as seawater, is run through a channel.

Many other chemicals are capable of blocking ion channels, he says, and «there is reasonable, if not compelling, evidence that a reduction in excitation is as much a part of the olfactory [sense] as excitation itself.»

As they did, the level of calcium ions in the neuron rose sharply, suggesting that ion channels had opened and the neuron was becoming active.

As part of the webinar series, Abcam would like to offer you a 50 % discount on the following product ranges: neuronal marker antibodies, Alexa Fluor ® conjugated secondary antibodies, agonists and antagonists, ion channel blockers and enzyme inhibitors and modulators.

Extensively expressed in animals, they were found in several bacteria, especially the homolog from the cyanobacteria Gloeobacter violaceus (GLIC) which functions as a proton-gated ion channel.

Ion channels play a critical role in physiology and many different biological processes such as neuronal signal transmission, muscle contraction, or T - cell activation.

Her team is currently examining the ion channels that open and close to allow the flow of ions as electrical impulses pass along the nerve cell membrane.

This work, published in the journal Nature, may help drive the discovery of new drugs such as local anesthetics and antiarrhythmics, which directly target this ion channel.

Used in experiments to understand biological processes and diseases and as part of the initial drug - discovery process, Tocris life science reagents include receptor ligands, ion channel modulators, enzyme inhibitors, caged compounds, fluorescent probes, and screening libraries.

Journal coverage includes basic signaling interests (e.g. neurotransmitters, ions and ion channels, receptors and messenger molecules, and kinases / phosphatases), as well as electrical signaling, signaling in neural circuits, neuroimaging, signaling aspects of pathologies, synaptic transmission and plasticity, and therapeutic intervention.

These broad associations with complexity are evidently superimposed on notable lineage - specific variation as seen in Fig. 4 (for example, serine protease gene loss in C. elegans, and voltage-gated ion channel expansion in Paramecium).

The basis of this technique is to genetically modify neurons to express light - sensitive ion channels such as excitatory channelrhodopsin or inhibitory halorhodospin and then use light to control the on / off status of neuronal excitation.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transportion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transportIon channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Mutations for mammoth hemoglobin, extra hair growth, fat production, down to nuanced climate adaptations such as slightly altered sodium ion channels in cell membranes have already been engineered into fibroblast cell lines.

The Lexicon efforts are focused on gene families that are pharmaceutically important, such as transporters, G - protein coupled receptors (GPCRs), ion channels, kinases and other key enzymes, membrane proteins (e.g., receptors), and secreted proteins.

This could be interpreted as UNC - 7L and UNC - 9 forming heteromeric channels, with ion selectivity properties that are influenced by both isoforms (as this dictates the rectification of Gj0), but Vj gating properties dominated by UNC - 7L (as this dictates the shape of the Gj ∞ plot).

We also utilise a number of optical methods including single cell imaging and photo - activated ion channels such as Channelrhodopsins.

Magnesium Sulfate reduces inflammation, relaxes muscles and blood vessels as well as modulates calcium ion channels within our cells, which trigger the release of neurotransmitters.

Mutations for monogenic epilepsies have been found primarily in genes coding for ion channels 32 as well as in two different proteins that may be involved in neurogenesis 33.