Sentences with phrase «ion channels using»

In the latter area, more than 50 % of drug discovery screens use cell ‑ based assays, predominantly targeting receptors and ion channels using fluorescence ‑ based measurements, in either or both high throughput and high ‑ content formats (1).

Not exact matches

Bound to the cell membrane, Na ± K+ATP ase uses the energy of adenosine triphosphate (ATP) molecules to pump sodium out of the cell and potassium into the cell, maintaining a charge gradient that allows ions to flow through open channels.

«Monobodies are refined and powerful enough to attack important questions in biology and medicine, such as the structure of the fluoride ion channel, but they can also be used to generate molecules that are almost immediately useful in industry.

A team of researchers at Columbia Engineering has used miniaturized electronics to measure the activity of individual ion - channel proteins with temporal resolution as fine as one microsecond, producing the fastest recordings of single ion channels ever performed.

They use charge in the form of ions to carry energy and information — ion channels control the flow of ions across cell membranes.

This small protein molecule contains a loop which fits, like a key in a lock, into the ion channel proteins found on nerve cell membranes, which are used to transport sodium and potassium ions in and out of the cell.

He and his group investigate the functional roles of ion channels and neurotransmitter receptors in neurons and glia using morphological, electrophysiological and molecular biological techniques.

Future studies will focus on using these nanobowls to deliver anle138b to the brain, as well as other diseased tissues and organs affected by toxic amyloid - beta ion channels.

The anti-epileptic medication currently in use, and the animal toxins mentioned above, reduce electrical excitability by closing a certain type of ion channel.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal because of an outer shield of amino acids called a turret situated above the channel's entrance.

During his postdoc, Dr. Taraska developed and used novel fluorescence methods to study the structure of ion channels in biological membranes.

It uses a virus already approved by the Food & Drug Administration for other genetic therapies in the eye; it delivers an ion channel gene similar to one normally found in humans, unlike others that employ genes from other species; and it can easily be reversed or adjusted by supplying new chemical photoswitches.

Using a device engineered by Nan Marie Jokerst, Ph.D., a professor of electrical and computer engineering at Duke's Pratt School of Engineering, the researchers showed that UVB caused calcium to flow into the skin cells, but only when the TRPV4 ion channel was present.

The virus inserts the therapeutic gene into the cell's DNA and uses its instructions to produce a receptor protein — a modified version of a common glutamate receptor ion channel - that they display on their surface.

Nerve cells rely on ion channels and pumps to orchestrate the continual ebb and flow of charged particles across the cell membrane, which enables the electrical signaling that nerves use to communicate.

A team of biophysicists from the State University of New York (S.U.N.Y.) at Buffalo used magnetic nanoparticles to control heat - activated protein gates called ion channels embedded in the membranes of nerve cells, allowing the researchers to stimulate a simple reflex in nematode worms at will.

He further explains that most previous work primarily used tiny magnets to open ion channels by pushing or pulling them in the right manner.

Used in experiments to understand biological processes and diseases and as part of the initial drug - discovery process, Tocris life science reagents include receptor ligands, ion channel modulators, enzyme inhibitors, caged compounds, fluorescent probes, and screening libraries.

The basis of this technique is to genetically modify neurons to express light - sensitive ion channels such as excitatory channelrhodopsin or inhibitory halorhodospin and then use light to control the on / off status of neuronal excitation.

BAZ2 - ICR (10 µm) was screened against a panel of 55 ligand receptors, ion channels and transports using an established and widely utilized commercial assay platform (ExpresSProfile; CEREP, Paris, FRANCE).

They used carbon nanotube porins (CNTPs), a technology they developed earlier at LLNL, which uses carbon nanotubes embedded in the lipid membrane to mimic biological ion channel functionality.