Importantly, the point mutations created by Agudelo et al. prevent ouabain binding to ATP1A1 but do not compromise
the ion pump's function or cause cellular growth delays.
«Our skilled doctoral students, Amanda Jonsson and Theresia Arbring Sjöström, have succeeded with the last important part of the puzzle in the development of
the ion pump.
Amanda Jonsson, who together with Theresia Arbring Sjöström is principal author of the article in Science Advances, has developed the pain - alleviating
ion pump as part of her doctoral studies.
All of the outputs of
the ion pump can also be rapidly switched on or off with the aid of micrometre - sized ion diodes.
With a microfabricated
ion pump built from organic electronic components, ions can be sent to nerve or muscle cells at the speed of the nervous system and with a precision of a single cell.
The ion pump delivered GABA directly to the rat's spinal cord.
Eighteen months ago, researchers at the Laboratory of Organic Electronics demonstrated
an ion pump which researchers at the Karolinska Institutet could use to reduce the sensation of pain in awake, freely - moving rats.
A study based on site - directed mutagenesis that changed the key amino acids within a bacterial
ion pump has produced a cesium pump, which could potentially extract cesium from the environment in the presence of light.
This is an end - on view of the vacuum chamber, showing
ion pump, which maintains the high vacuum, to the left, and the photomultiplier tube and light collection lenses to the right.
Similar ATPase enzymes were subsequently discovered, including
the ion pump that controls muscle contraction.
Contracting muscles of the heart, diaphragm and limbs;
ion pumps that maintain the electrical properties of nerves; and biochemical reactions that break down food and synthesize new tissues (to name a few) generate body heat continuously.
«Our results provide new insight into a generalized circuit model, enabling us to determine the conditions to maximize the efficiency of harnessing chemical energy through the action of
these ion pumps.
In living systems, energy is stored in potentials across lipid membranes, in this case created through the action of
ion pumps.
She proudly presents a glass disk with many of the new miniaturized
ion pumps.
Some jellyfish, algae and bacteria produce light - activated
ion pumps and channels.
Magnesium - powered
ion pumps maintain those specific concentrations.
Specifically, it is important for
the ion pumps that control signaling between the neurons of the brain.
Not exact matches
«Half the calories a brain burns go towards simply keeping the structure intact by
pumping sodium and potassium
ions across membranes to maintain an electrical charge,» according to the video.
To compensate, the «excited» cell
pumps in calcium
ions.
Bound to the cell membrane, Na ± K+ATP ase uses the energy of adenosine triphosphate (ATP) molecules to
pump sodium out of the cell and potassium into the cell, maintaining a charge gradient that allows
ions to flow through open channels.
This is because rat neurons are much more efficient at
pumping ions into the cell than squid neurons, say the team, resulting in squid using up more energy to generate a charge and transmit the signal.
To transmit electrical signals along a neuron, a strong difference in charge between the interior and exterior of the cell is needed, which is created by
pumping positive
ions into the cell.
(1) Using a laser, the
ion spin chain is optically
pumped to a spin state that is uncorrelated with respect to the spin - spin interactions.
Living systems achieve this functionality with their own version of electronics based on lipid membranes and
ion channels and
pumps, which act as a kind of «biological transistor.»
For example, ATP1B1 encodes a sub-unit of the sodium - potassium plasma membrane
pump, which is essential for water and
ion transport.
Although electrolyte leakage is still undesired, its danger is minimized by the use of either the normal saline solution
pumped into the body in most IV treatments or a cell - culture medium that contains amino acids, sugars, and vitamins in addition to sodium
ions and thus mimics the fluid that surrounds human cells.
The acid
pump does something similar, but this time with hydrogen instead of sodium
ions — and with the crucial difference that the acid
pump does not generate a current.
The research team was also able to identify the exact mechanism of the
pump's targeting and transport of particular
ions.
It does so by
pumping protons — or hydrogen
ions — out of the cell and into the environment, where their concentration is higher.
The conducting polymer in the control electrode becomes charged with
ions when the
pump is switched off.
Most tunable femtosecond lasers use expensive and bulky argon -
ion lasers to feed green «
pump» light into the device.
«The sperm
pumps out calcium and takes in hydrogen
ions, which seems to give it that last push into the egg, and also is critical to starting the zygote's life.»
When CO2 is
pumped into underground porous rocks, it combines with metal
ions in the salty water that fills the rock pores and mineralizes into mineral carbonates, such as calcium carbonate (CaCO3).
In the time - lapse video above, taken as the battery is charged by electrons
pumping into the tin oxide, lithium
ions can be seen streaming though the hollow nanowire to pair with the electrons.
Nerve cells rely on
ion channels and
pumps to orchestrate the continual ebb and flow of charged particles across the cell membrane, which enables the electrical signaling that nerves use to communicate.
One characteristic of almost all living cells is that they
pump ions across a membrane to generate an electrochemical gradient, then use that gradient to make the energy - rich molecule ATP.
The process involves
pumping positively charged hydrogen
ions, called protons, across a membrane.
The same transmitter, acetylcholine, can independently stimulate both a chloride
ion conductance and a sodium
pump mechanism in the same follower cell by acting on two different postsynaptic receptors.
«Once inside the cell, cadmium inserts itself into the cell's metal sensing machinery causing it to malfunction and
pump out the wrong metal
ions while still bringing in more cadmium.
Typically, these calcium
ions are then
pumped back into storage, allowing the muscle to relax before it receives any further nerve impulses, but fish swimbladder muscles contract too quickly for this
pumping phase to be completed before the next contraction begins.
These calcium
ions can then be slowly
pumped back into storage during the silent periods that punctuate the toadfish's calls.
«The combination of fast calcium
pumping and small calcium release permits the midshipman to maintain the correct balance of calcium
ions during its long - lasting mating call,» Rome says.
Also,
ions are
pumped across cell membranes by proteins creating necessary energy reservoirs for the cell.
The Na / K
pump operates by transporting two potassium
ions into your cells while moving three sodium
ions out of your cells.
Chevrolet Cobalt and Pontiac G5 models built between the 2007 and 2009 model years are subject to a General Motors recall, as are 2007 model Chevrolet Equinox, Pontiac Torrent, and Saturn
ION models for a faulty fuel
pump module on units sold in Arizona, California, Florida, Nevada, and Texas.
Hybrid / EV / hydrogen battery (nickel - metal hydrate or lithium -
ion drive propulsion battery) including the case and mounting hardware, junction block, main battery cable, and frame wire; onboard battery charging system including charge controller, plug in outlets, plug in cable, and trickle charger cable; electric AC compressor and motor; electric steering rack, gear, and motor; electro / hydraulic power steering
pump and reservoir; hydrogen fuel cell stack; seals and gaskets.
[45] Other features include a 42.4 kWh liquid cooled lithium -
ion battery pack, a need - based energy management system, LED technology used for all lighting units, independent cooling system for each axle; doors, covers, sidewalls and roof in carbon fibre - reinforced plastic; 3 - mode flush gear selector (forward, reverse and neutral), instrument cluster with fold - out central display with integrated Audi MMI functions, climate control unit located to the right above the steering wheel, racing - inspired lightweight bucket seats, snow white and cognac interior colours, heat
pump, climate control system; triangular double wishbones at the front axle and trapezoidal wishbones made of forged aluminum components at the rear axle, direct rack - and - pinion steering with speed - sensitive electromechanical steering boost, 235 / 35R19 front and 295 / 30R19 rear tires with a new blade design and the prototype version of an information processing system (car - to - x communication).
A 20kWh, air - cooled lithium -
ion battery pack made by Toshiba adds 700 pounds to the vehicle's weight and powers the electric motor, which
pumps out 123 hp at 3,695 rpm and 189 lb - ft of torque right from 0 rpm.
IP25, tri-unsaturated HBI (HBI - III, Z - isomere41), and sterols were analyzed by gas chromatography (GC) using an Agilent Technologies 7890B (30 m DB - 1MS column, 0.25 mm i.d., 0.25 µm film thickness) coupled to an Agilent Technologies 5977A Extractor mass selective detector (MSD, 70 eV constant ionization potential, Scan 50 — 550 m / z, 1 scan / s,
ion source temperature 230 °C, Performance Turbo
Pump).
To overcome the limiting supply of CO2, organisms like coral concentrate bicarbonate
ions in compartments into which they
pump H +
ions and lower the pH. As seen in Figure 2, at pH 5 or lower, 90 % of the DIC converts to CO2.