Sentences with word «irinotecan»

Lee says the research team will measure the amount of methylation in patients» cells when they begin their treatment and the presence of genes associated with irinotecan resistance, among other possible biomarkers.
The UCLA research team designed a nanoparticle comprised of a hollow silica core surrounded by a lipid bilayer to enhance the delivery of irinotecan in an animal model with pancreatic cancer.
A new animal model of intestinal mucositis induced by the combination of irinotecan and 5 - fluorouracil in mice.
The chemotherapy drug irinotecan is linked to glucuronic acid to mark it for elimination, and when the GI bacteria remove the sugar, they release a virulently toxic drug back into the intestines.
ATM - dependent activation of p53 is usually induced by many — if not all — types of DNA - damage drugs, including camptothecin compounds such as irinotecan and topotecan, leading the authors to conclude that FL118's mechanisms of action are distinct among camptothecin analogues.
A Phase I Trial of outpatient Weekly irinotecan / carboplatin and concurrent radiation for Stage III unresectable non-small-cell lung cancer.
36) Gao K, Lockwood WW, Li J, Lam WL, Li G (2008) Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.
Phase I Clinical Trial of VX - 970 in Combination with the Topoisomerase I Inhibitor Irinotecan in Patients with Advanced Solid Tumors
In 2015, Onivyde — a similar combination therapy involving irinotecan liposome injection in combination with fluorouracil and leucovorin — was approved for the second - line treatment of patients with metastatic pancreatic cancer.
Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor - bearing DA rats
Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor - bearing DA rats
Their findings led directly to the Food and Drug Administration's 2004 decision mandating that the label for irinotecan be amended with pharmacogenomic data alerting physicians to the increased risk.
The NAPOLI - 1 (NAnoliPOsomaL Irinotecan) Phase 3 study — a final confirmation of a drug's safety and effectiveness — was conducted among patients with metastatic pancreatic cancer who previously received gemcitibine, which has been the standard - of - care therapy for such patients.
The abstract title was: CTC 11 - 001: Phase I study of Carfilzomib (C) + Irinotecan (I) in relapsed solid tumors.
This causes diarrhea in up to 90 % of patients who take irinotecan.
Redinbo and his team now characterize various forms of Beta - glucuronidase produced by different strains of bacteria residing in the gut, and they show that inhibiting GI bacterial Beta - glucuronidases in mice does not affect irinotecan that is circulating in the blood and is needed to combat cancer.
Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved in cell and DNA replication, slowing the uncontrolled growth of tumor cells.
The investigators used the nanoparticle plus the iRGD to deliver irinotecan in a robust animal model for pancreatic cancer that closely mimics human disease.
Patients responded to irinotecan at the same rate whether they had low or high levels of these genes.
This finding suggests that physicians might want to select irinotecan as the first - choice chemotherapy for patients with high ERCC1 or TS levels.
«Several large trials compared oxaliplatin and irinotecan head - to - head and concluded that the response rate is about equal.
This is the first study to evaluate the safety and clinical activity of the combination of oral pazopanib, intravenous or oral irinotecan, and oral temozolomide in pediatric and young adult patients with relapsed or refractory sarcomas.
Irinotecan causes severe diarrhea and neutropenia, a decrease of white blood cells, in 20 percent to 35 percent of patients.
Ratain, for example, got his start in the field studying irinotecan, a drug used to fight colorectal cancer.
Dr. Innocenti is a co-inventor of the FDA - approved UGT1A1 genetic test for patients treated with irinotecan.
Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer.
«While FL118 is an analogue of irinotecan and topotecan, two FDA - approved cancer drugs that are also based on the naturally occurring compound camptothecin, our findings add further evidence that FL118 has novel mechanisms of action that may make it especially potent against solid tumors and especially effective as a well - tolerated, targeted therapy,» said Dr. Li, an Associate Professor of Oncology in the Department of Pharmacology and Therapeutics.
Weekly irinotecan and cisplatin in advanced non-small cell lung cancer: A phase II multicenter study.
Patients with metastatic pancreatic cancer that has progressed after receiving gemcitabine - based chemotherapy now have a new treatment option: irinotecan liposome in combination with fluorouracil and leucovorin.
By reversing this change in cancer cells, the drug restores cancer cells» vulnerability to drugs such as irinotecan.
Phase I / II Study to Evaluate the Safety, Efficacy, and Novel PET / CT Imaging Biomarkers of CB - 839 in Combination with Panitumumab and Irinotecan in Patients with Metastatic and Refractory RAS Wildtype Colorectal Cancer
The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.
Findings were presented at the WCLC are based on the updated results of 12 lung cancer patients enrolled in the clinical trial with pembro and irinotecan or gemcitabine with or without vinorelbine or docetaxel.
The «PembroPlus» clinical trial launched in January 2014 and combines more traditional chemotherapy drugs (gemcitabine, docetaxel, nab - paclitaxel, vinorelbine, irinotecan, and / or liposomal doxorubicin) with immunotherapy (pembrolizumab), activating the body's own immune system to improve upon results that may be achieved from chemotherapy alone.
Previous research by Redinbo and others revealed that inhibiting Beta - glucuronidase helps reduce the GI toxicity associated with irinotecan, suggesting that bacteria are responsible for the drug's side effects.
Here's one example of how this information might be useful for doctors and patients: Irinotecan is a drug only indicated by the FDA for use in colon cancer.
Importantly, like cancer cells with other mutations in the HR repair pathway, CHD1 - depleted prostate cancer cells proved to be hypersensitive to chemotherapeutic drugs causing DNA breaks, such as Mitomycin C, Irinotecan and PARP inhibitors.
The researchers proposed that the therapeutic benefit of the irinotecan containing nanoparticles may be enhanced when combined with the injection of iRGD.
The introduction of nanocarriers as delivery vehicles for common chemotherapy agents such as the drug irinotecan, has led to improved survival of patients with this disease.
Metastatic colorectal cancer, the third deadliest cancer in the Unites States, is typically treated with two chemotherapy drugs, 5 - Fluorouracil in combination with either oxaliplatin or irinotecan.
The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.
Scientists leading the new study will also look for biomarkers in patients that could help determine which of them are most likely to benefit from guadecitabine and irinotecan.
In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI - 110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.
The clinical trial included 22 patients with metastatic colorectal cancer who had been treated previously with irinotecan and whose disease was progressing.
The patients were divided into four groups, each receiving different doses of guadecitabine in combination with irinotecan, over an average period of four months.
The spectrum of resistances induced by this mechanism is extensive and includes drugs commonly used in the treatment of these cancers, such as as 5 - fluorouracil, oxyplatinum or irinotecan, but also drugs targeting recent molecular targets such as kinase inhibitors.
While thousands of agents based on camptothecin have been synthesized, and two of these analogs — irinotecan and topotecan — have been approved for treatment of many solid - tumor cancers, these compounds typically are highly toxic to healthy cells, and not all of them have proven effective as anticancer agents.
The new compound targets topoisomease I, an enzyme that is already exploited for cancer chemotherapy by topotecan and irinotecan.
Choy, H, Chakravarthy, A. Phase I trial of Irinotecan and concurrent radiation therapy for stage III non-small cell lung cancer.
a b c d e f g h i j k l m n o p q r s t u v w x y z