Palifermin reduces diarrhea and increases survival following
irinotecan treatment in tumor - bearing DA rats
Velafermin improves gastrointestinal mucositis following
irinotecan treatment in tumor - bearing DA rats
Not exact matches
Lee says the research team will measure the amount of methylation in patients» cells when they begin their
treatment and the presence of genes associated with
irinotecan resistance, among other possible biomarkers.
While thousands of agents based on camptothecin have been synthesized, and two of these analogs —
irinotecan and topotecan — have been approved for
treatment of many solid - tumor cancers, these compounds typically are highly toxic to healthy cells, and not all of them have proven effective as anticancer agents.
Treatment of the Gb3 - expressing gastric carcinoma cell line St3051 with STxB coupled to SN38, the active metabolite of the topoisomerase type I inhibitor
irinotecan, resulted in > 100-fold increased cytotoxicity, as compared with
irinotecan alone.