A new, specially
coated iron oxide nanoparticle developed by a team at MIT and elsewhere could provide an alternative to conventional gadolinium - based contrast agents used for magnetic resonance imaging (MRI) procedures.
Gao and Koo reached out to Cormode, who had experience working
with iron oxide nanoparticles in a radiological imaging context, to help them synthesize, characterize and test the effectiveness of the nanoparticles, several forms of which are already FDA - approved for imaging in humans.
The Bulte Lab has developed methods to label cells magnetically using tiny superparamagnetic
iron oxide nanoparticles in order to make them visible by magnetic resonance imaging; this technology has now been introduced in the clinic for several cell therapy applications.
As an alternative, contrast agents based
on iron oxide nanoparticles are practically unused because of the difficult readability of the results.
Previously, the IBS team designed ultrasmall
T1 iron oxide nanoparticles (PEG - IONCs), proved the possibility to synthesize them in large quantities, and tested them on mice.
Napier's presentation, titled «
Superparamagnetic Iron Oxide Nanoparticles for Delivery of DNA - based Contraceptive Vaccines for Feral Cats,» dealt with a portion of Napier's research in developing and delivering contraceptives to feral cats.
Mitragotri reckons that the particles could provide a way to get drugs into the body at a more constant concentration, or substances such
as iron oxide nanoparticles, which increase contrast in magnetic resonance imaging.
HST researchers have experimented with polymer - coated
iron oxide nanoparticles held together by DNA tethers to help them create a visual image of a tumor through magnetic resonance imaging.
Researchers at Umeå University, together with researchers at Uppsala University and Stockholm University, show in a new study how nitrogen doped graphene can be rolled into perfect Archimedean nano scrolls by adhering
magnetic iron oxide nanoparticles on the surface of the graphene sheets.
I've been experimenting with T10 dextran
coated iron oxide nanoparticles, obviously not the same as fullerenes, but still a very interesting tool, I've been testing if the coating is giving the particle antioxidant abilities because of it's the (basically) indigestable sugar chains (glucose) creating a high surface area which are largely made from hydroxyl groups, I hypothesised this act's as a «sink» for reactive oxygen species converting them to water.
Previously, the Institute for Basic Science (IBS) team designed ultra-small
T1 iron oxide nanoparticles (PEG - IONCs), proving the possibility to synthesise them in large quantities.
Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy Gang Huang, Huabing Chen, Ying Dong, Xiuquan Luo, Haijun Yu, Zachary Moore, Erik A. Bey, David A. Boothman, Jinming Gao Theranostics 2013; 3 (2): 116 - 126.
Less often used are contrast agents made
from iron oxide nanoparticles, which are considered somewhat safer because the body already contains iron.
In the decoration process one can control the type
of iron oxide nanoparticles that are formed on the graphene surface, so that they either form so called hematite (the reddish form of iron oxide that often is found in nature) or maghemite, a less stable and more magnetic form of iron oxide.
An iron oxide nanoparticle applied to teeth prior to treatment with hydrogen peroxide effectively reduced the onset and severity of cavities (indicated with red arrows) in rats.
Yet, to be effective, the size of
the iron oxide nanoparticles had to be just right — and had to be maintained in a strong matrix that was both flexible and resilient to deal with large volume changes while optimally conducting electricity.
In that study, Gao showed that
an iron oxide nanoparticle behaved similarly to a peroxidase, an enzyme found naturally that catalyzes oxidative reactions, often using hydrogen peroxide.
The researchers planted wheatgrass seeds in multiple replicates in cotton wool and fed them with dispersions that contained raw single - walled or multi-walled nanotubes, purified single - walled nanotubes or
iron oxide nanoparticles that mimicked leftover catalyst often attached to nanotubes.
The researchers were able to rapidly generate uniform heat throughout frozen tissues by mixing tiny silica - coated
iron oxide nanoparticles, each one with a diameter 150 times smaller than a red blood cell, into the cryopreservation solution used for vitrification.
By this method they obtain anchoring sites for
the iron oxide nanoparticles that are decorated onto the graphene sheets in a solution process.
The nanoscrolls can be visualized as traditional «Swiss rolls» where the sponge - cake represents the graphene, and the creamy filling is
the iron oxide nanoparticles.
Moreover, they showed that by removing
the iron oxide nanoparticles by acid treatment the nanoscrolls again open up and go back to single graphene sheets
It shows that the magnetic interaction between
the iron oxide nanoparticles is one of the main effects behind the scroll formation.
The NTU scientists create micro-sized gas bubbles coated with cancer drug particles and
iron oxide nanoparticles, and then use magnets to direct these bubbles to gather around a specific tumour.
A comprehensive analysis of transfection - assisted delivery of
iron oxide nanoparticles to dendritic cells.
A 2017 study co-authored by John Bischof, professor of mechanical engineering at the University of Minnesota, and published in Science Translational Medicine, used specially coated
iron oxide nanoparticles.