The Bulte Lab has developed methods to label cells magnetically using tiny superparamagnetic
iron oxide nanoparticles in order to make them visible by magnetic resonance imaging; this technology has now been introduced in the clinic for several cell therapy applications.
Gao and Koo reached out to Cormode, who had experience working with
iron oxide nanoparticles in a radiological imaging context, to help them synthesize, characterize and test the effectiveness of the nanoparticles, several forms of which are already FDA - approved for imaging in humans.
Not exact matches
Mitragotri reckons that the particles could provide a way to get drugs into the body at a more constant concentration, or substances such as
iron oxide nanoparticles, which increase contrast
in magnetic resonance imaging.
An
iron oxide nanoparticle applied to teeth prior to treatment with hydrogen peroxide effectively reduced the onset and severity of cavities (indicated with red arrows)
in rats.
Yet, to be effective, the size of the
iron oxide nanoparticles had to be just right — and had to be maintained
in a strong matrix that was both flexible and resilient to deal with large volume changes while optimally conducting electricity.
In that study, Gao showed that an
iron oxide nanoparticle behaved similarly to a peroxidase, an enzyme found naturally that catalyzes oxidative reactions, often using hydrogen peroxide.
A combination of
iron -
oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumors
in mice according to an accepted manuscript by Dartmouth - Hitchcock Norris Cotton Center researchers
in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.
An endowed professor of pediatric cardiology at Children's Hospital of Philadelphia
in Pennsylvania, Levy had been working with his team on biodegradable polymer
nanoparticles infused with
iron oxide.
Previously, the IBS team designed ultrasmall T1
iron oxide nanoparticles (PEG - IONCs), proved the possibility to synthesize them
in large quantities, and tested them on mice.
Researchers at Umeå University, together with researchers at Uppsala University and Stockholm University, show
in a new study how nitrogen doped graphene can be rolled into perfect Archimedean nano scrolls by adhering magnetic
iron oxide nanoparticles on the surface of the graphene sheets.
By this method they obtain anchoring sites for the
iron oxide nanoparticles that are decorated onto the graphene sheets
in a solution process.
HYEON Taeghwan, director of the Center for
Nanoparticle Research explains: «Let's take the example of a MRI analysis of a brain with Alzheimer's:
iron oxide in the blood vessels would appear as black and the amyloid plaques as gray.
In place of gadolinium - based contrast agents, the researchers have found that they can produce similar MRI contrast with tiny
nanoparticles of
iron oxide that have been treated with a zwitterion coating.
To get round this, Wilhelm Roell at the University of Bonn
in Germany and his colleagues loaded muscle stem cells with
iron oxide nanoparticles to make them magnetic.
The team used
iron oxide for the core of the
nanoparticles, which not only enables the team to use them for magnetic resonance imaging, but opens up possibilities
in remote guidance and localized magnetic heating to hasten the breaking up of the clots.
«Deficient neuron - microglia signaling results
in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks
in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study
in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization of hydrophobic
iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.
Previously, the Institute for Basic Science (IBS) team designed ultra-small T1
iron oxide nanoparticles (PEG - IONCs), proving the possibility to synthesise them
in large quantities.
A 2017 study co-authored by John Bischof, professor of mechanical engineering at the University of Minnesota, and published
in Science Translational Medicine, used specially coated
iron oxide nanoparticles.
Napier's presentation, titled «Superparamagnetic
Iron Oxide Nanoparticles for Delivery of DNA - based Contraceptive Vaccines for Feral Cats,» dealt with a portion of Napier's research
in developing and delivering contraceptives to feral cats.