In the last few years, several studies have shown that iron deficiency, which affects around two billion people worldwide, may be a risk factor for
ischaemic stroke in adults and in children.
Dr Al - Khalili said: «Even through these patients are classified as low risk, the incidence of
ischaemic stroke in our study population is neither negligible nor ignorable and it carries a relatively high mortality.»
An irregular heart rhythm, or atrial fibrillation, was significantly associated with
ischaemic stroke in all regions, but was of greater importance in Western Europe, North America and Australia, than in China or South Asia.
Not exact matches
Previous studies have combined
ischaemic and haemorrhagic
stroke probably due to the limited number of
stroke cases
in their datasets.
The increase
in longevity, especially
in high - income countries (HICs), has been largely due to the decline
in deaths from cardiovascular disease (
stroke and
ischaemic heart disease), mainly because of simple, cost - effective strategies to reduce tobacco use and high blood pressure, and improved coverage and effectiveness of health interventions.
The findings show just how important it is for people with acute
ischaemic stroke (
in which blood flow to an area of the brain is blocked or reduced) to be identified quickly and treated by specialist staff
in order to reduce the subsequent degree of disability.
This compares with complete recovery for one
in five people and death
in one
in five after an
ischaemic stroke.
The overall mortality was 7.5 per 1000 patient - years
in patients without
ischaemic stroke, and 29.6 per 1000 patient - years
in patients who had suffered an
ischaemic stroke during follow - up.
In the multivariable analysis, the only variables that remained significantly associated with an increased risk of
ischaemic stroke were age (hazard ratio [HR] 1.06, 95 % confidence interval [CI] 1.05 - 1.08, p < 0.001 per incremental year) and alcohol related hospitalisation (HR 2.01, 95 % CI 1.45 — 2.79, p < 0.001).
As a result, the decrease
in salt intake would have played an important role
in the reduction
in stroke and
ischaemic heart disease mortality during this period.»
We also performed subgroup meta - analyses by type of prevention (primary v secondary:
in this study, trials involving healthy populations or patients with any specific disease except for cardiovascular disease were classified as primary prevention trials, and trials involving patients with cardiovascular disease were classified as secondary prevention trials), type of supplement by quality and dose (each supplement, vitamins only, antioxidants only, or antioxidants excluding vitamins), type of outcome (cardiovascular death, angina, fatal or non-fatal myocardial infarction,
stroke, or transient
ischaemic attack), type of outcome
in each supplement, type of study design (randomised, double blind, placebo controlled trial v open label, randomised controlled trial), methodological quality (high v low), duration of treatment (< 5 years v ≥ 5 years), funding source (pharmaceutical industry v independent organisation), provider of supplements (pharmaceutical industry v not pharmaceutical industry), type of control (placebo v no placebo), number of participants (≥ 10000 v < 10000), and supplements given singly or
in combination with other vitamin or antioxidant supplements by quality.
Despite the modest reduction
in blood pressure, it could be significant as even a 2 mmHg diastolic blood pressure decrease has the potential to reduce coronary heart disease risk by 6 % and transient
ischaemic attack and
stroke risk by 15 %.
An efficacy and safety comparison between different stentriever designs
in acute
ischaemic stroke: a systematic review and meta - analysis.
The impact on health is immense: Air pollution was responsible
in 2015 for 19 % of all cardiovascular deaths worldwide, 24 % of
ischaemic heart disease deaths, 21 % of
stroke deaths, and 23 % of lung cancer deaths.