Sentences with phrase «ischemia model»

We then evaluated whether the encapsulation of hPSC - CDH5 + cells in PA - RGDS could enhance long - term cell survival and vascular regenerative effects in a hind - limb ischemia model with laser Doppler perfusion imaging, bioluminescence imaging, real - time reverse transcription - polymerase chain reaction, and histological analysis.

The chitosan gel resembles the alginate material used to encapsulate cells by the Taylor lab. Yoon's team was testing efficacy in a hindlimb ischemia model, in which a mouseâ $ ™ s leg is deprived of blood.

GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards cardiac tissues [47 - 49].

Not exact matches

Key aspects of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2 - sensing HIF (hypoxia - inducible factor) hydroxylase EGL - 9.

Powers is planning expand his study size and is partnering with another CCTS - funded stroke investigator who developed an animal model of ischemia in order to analyze micro-RNA released in brain tissues at the precise area around a blocked blood vessel.

Current projects are investigating: 1) the expression of inflammatory genes during ischemia and reperfusion of kidneys during urology transplantation and in mouse models; 2) the expression of inflammatory genes and proteins in urine as markers indicating the presence of rejection in renal allografts; and 3) the role of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.

Using a rat model of chronic pelvic ischemia developed at the Wake Forest Institute for Regenerative Medicine, the project has shown that a chronic reduction of blood flow to the lower urinary tract can contribute to dysfunction.

Characterization of Neuroprotective Effects of Biphalin, an Opioid Receptor Agonist, in a Model of Focal Brain Ischemia.

The team currently is studying the use of gene and stem cell therapy in mouse models of critical limb ischemia and cutaneous burn wounds.

The team applied combined murine models of muscle injury and hind limb ischemia to investigate two potential mechanotherapies: an implanted magnetic biocompatible gel and an external, soft robotic pressurized cuff.