Not exact matches
Earlier studies in STEMI patients showed that
ischemic postconditioning improved ST - segment resolution — an important marker of arterial blockage on electrocardiogram — reduced
damage to
heart muscle, and in some patients limited the extent of reperfusion injury.
Dr. Srivastava has co-founded a biotechnology company to help find new cures for many human diseases and one of the developmental genes whose role he discovered, Thymosin β4, is currently in clinical trials for patients suffering
ischemic damage to the
heart.
We are now moving this discovery into Phase II clinical trials (FDA approved) in patients suffering
ischemic damage to the
heart.
The major outcome of
ischemic damage is aggravation of the
heart muscle function, known as cardiomyopathy.
In animals, these cells quickly repaired vascular
damage, cutting the death rate after a
heart attack in half and restoring the blood flow to
ischemic limbs that might otherwise have to be amputated.
Okyanos cardiac cell therapy targets the restoration of blood flow to the
heart and repairs
damaged heart tissue caused by
heart attack or
ischemic and non-
ischemic heart disease.
More interestingly, the effects on infarction size, survival rates and cardiac function can be observed even if the dietary intervention is induced after the
ischemic event, by increasing the expression of angiogenic factors and increased vascularization of the
damaged myocardium, proposing a novel non-pharmacological therapy for subjects with chronic
heart failure (43).