Further study of these mice showed that activating HIF - 1 in the cells appeared to turn on a number of genes that help these cells not only home to
the ischemic limb, but to stay there once they arrive.
We found that when we injected these cells into a damaged,
ischemic limb, there was almost 100 percent restoration of blood flow in a month.
In animals, these cells quickly repaired vascular damage, cutting the death rate after a heart attack in half and restoring the blood flow to
ischemic limbs that might otherwise have to be amputated.