Sentences with phrase «islet cell dysfunction»

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«In the study we challenged the view that the age - dependent impairment in glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of Miami.

Dysfunction and loss of β cells has been associated with glucolipotoxicity (Poitout and Robertson, 2002; El - Assaad et al., 2003), islet cholesterol accumulation (Brunham et al., 2010), and islet inflammation (Donath and Shoelson, 2011).

To evaluate islet dysfunction and β cells damage, we studied islet morphology by staining α -, β -, and δ cells using anti-glucagon, anti-insulin, and anti-somatostatin antibodies, respectively (Fig. 4 D).

However, compelling evidence suggests that accumulation of amyloid aggregates in the islets of Langerhans might significantly contribute to β cell dysfunction and disease (Hull et al., 2004; Haataja et al., 2008; Jurgens et al., 2011; Mukherjee et al., 2015).

Tissue inhibitor of metalloproteinase - 1 prevents cytokine - mediated dysfunction and cytotoxicity in pancreatic islets and beta - cells.

The far more nuanced and precise data produced by single cell analyses will allow for better understanding of pancreatic islet function and dysfunction at the cellular level.

Unfortunately, conventional sorting techniques have not been sufficient to isolate the individual islet cell types, making it impossible to analyze each one's gene expression program and its potential contribution to dysfunction.

Antibodies against the inflamed pancreatic cells are created and this process leads to dysfunction and destruction β - cells of the islets of Langerhans where insulin is produced.