Sentences with phrase «islet cell mass»

The mice that received the therapy had 10 times higher islet cell mass, three times higher insulin levels and improved insulin sensitivity and islet cell survival compared to the untreated mice.

Inhibition of DPP - 4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.

Not exact matches

When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.

Autopsy studies in humans suggest that islet amyloid is associated with the loss of β cells mass (Clark et al., 1988).

Diabetes due to a progressive defect in β - cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): A new model for type 2 diabetes

Type 2 diabetes (T2D) mellitus is characterized by hyperglycemia, insulin resistance, defective insulin secretion, loss of β cell function and mass, and accumulation of amyloid in the islets of Langerhans (Stumvoll et al., 2005).

Chen C, Chmelova H, Cohrs CM, Chouinard JA, Jahn SR, Stertmann J, Uphues I, Speier S Alterations in β - cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset.

hASC treatment also mediated a significant preservation of insulin staining and β cell mass, boosted β cell number, and also induced β cell proliferation, while hASC - conditioned medium (hASC - CM) was also able to support mouse islet survival after dissociation in vitro.