Sentences with phrase «islet cells as»

Most cases of type 1 diabetes occur when the body mistakenly sees the islet cells as a foreign invader and wrecks the thing.

Not exact matches

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet cells in the pancreas to survive.

Pancreatic neuroendocrine tumors, often referred to as «islet cell tumors» are a type of cancer that arises from hormone - releasing cells in the pancreas.

The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantaIslet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatCell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantaislet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantaislet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatcell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantation.

Kim and his colleagues are planning to continue their studies of pancreatic and islet - cell development as part of a Stanford focus on diabetes and metabolism research.

Whatever the source of pluripotent cells, Thomson says, researchers face the same scientific challenges — namely, understanding how to convert them into key tissues such as the beta islet cells that are impaired in diabetics, and then how to introduce them safely and effectively into humans.

When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.

Accounting for about 1 percent of all pancreatic cancers, pNET is a cancer of the endocrine cells, known clinically as the islets of Langerhans, which exist in small clusters throughout the pancreas.

As before, abnormalities of islet morphology and β cells loss were studied by staining α -, β -, and δ - cells using anti-glucagon, anti-insulin, and anti-somatostatin antibodies, respectively (Fig. 7 C).

The remaining islet cell tumors may produce other hormones, such as vasoactive intestinal polypeptide, which can cause severe diarrhea and lead to dehydration.

In the group of mice treated with synthetic IAPP aggregates, we observed a substantial reduction in the area of islets occupied by β cells as compared with controls untreated or treated with the same concentration of nonaggregated IAPP (Fig. 7 D).

The area of the islets occupied by β cells was significantly reduced in the Tg / Tg group, as compared with control mice.

Although cord blood stem cell transplant is becoming increasingly promising, the Clinical Islet Program is not currently involved with cord blood as a treatment for diabetes.

In addition, the molecular beacons technique http://www.lependart.com could have broad applications across regenerative medicine, because it could be used with other types of cells produced from stem cell cultures, such as brain cells or insulin - producing islet cells.

Complementing this work are recent advances at Joslin identifying new islet growth in patients with long - standing type 1 diabetes, as well as identifying potential islet growth factors, which occur in situations of insulin resistance, that could be used to stimulate the growth of the patient's own beta cells.

ViaCyte's PEC - EncapTM (also known as VC - 01TM) product candidate is the first pluripotent stem cell - derived islet cell replacement therapy for the treatment of type 1 diabetes in clinical - stage development.

In addition to providing an unlimited supply of cells for implantation, the PEC - Direct approach has the potential to provide other advantages relative to cadaver islet transplants such as delivering a more consistent product preparation under quality - controlled cGMP conditions, with a more straightforward and safer mode of delivery.

«I'm a big proponent of islet cell transplantation for type 2 diabetics,» says Dr. Gordon Weir, who is one of the world's foremost experts on islet cell transplantation as Co-Head...

Coating Human Pancreatic Islets With CD4 + CD25highCD127 - Regulatory T Cells as a Novel Approach for the Local Immunoprotection.

Once implanted, the cells are designed to differentiate into the various cell types that make up the pancreatic islet, which could allow for production of insulin and other hormones, such as glucagon, needed to control blood sugar levels.

«I highly respect Novocell technologies and am pleased to collaborate with Novocell and explore the potential of their hES cell to islet cell advances in combination with our iPS cells as a potential new sources for the generation of cellular models and therapies for diabetes,» said Dr. Yamanaka, Director of Center for iPS Research and Application at Kyoto University.

«These results suggest that, as a result of the FMD and re-feeding cycle, the pancreatic islets contain an elevated number of cells with features of progenitor cells, which may differentiate and generate insulin - producing cells,» noted the research.

In addition, the funding will be used to support other operations including the continued development of the PEC - Encap ™ product candidate, ViaCyte's stem cell - derived islet replacement therapy that is being developed as a treatment for all diabetes patients who require insulin to control their disease.

In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.

San Diego, California, October 6, 2014 — ViaCyte, Inc., a privately - held regenerative medicine company developing a stem cell - derived islet replacement therapy for the treatment of diabetes, called VC - 01 ™, will give two presentations at the annual Stem Cell Meeting on the Mesa Conference, being held at the Estancia La Jolla Hotel & Spa and The Salk Institute for Biological Studies, as follcell - derived islet replacement therapy for the treatment of diabetes, called VC - 01 ™, will give two presentations at the annual Stem Cell Meeting on the Mesa Conference, being held at the Estancia La Jolla Hotel & Spa and The Salk Institute for Biological Studies, as follCell Meeting on the Mesa Conference, being held at the Estancia La Jolla Hotel & Spa and The Salk Institute for Biological Studies, as follows:

TIMP - 1, previously described as being able to protect against cytokine and STZ ‐ induced β cell death [5, 6], was one of the most enriched factors in co-culture experiments using mouse and human islet cells, and the authors found that TIMP - 1 was induced by pro-inflammatory factors which are commonly associated with T1DM.

The PEC - Encap (also known as VC - 01) product candidate is designed to deliver stem cell - derived islet replacement therapies to patients with type 1 diabetes as well as patients with type 2 disease that require insulin.

One hypothesis is that beta cells in some islets may remain dormant until needed, and thus not age as quickly, Bonner - Weir says.

In addition to providing an unlimited supply of cells for implantation, the PEC - Direct approach has other potential advantages relative to cadaver islet transplants such as delivering a more consistent product preparation under quality - controlled cGMP conditions, and a more straightforward and safe mode of delivery.

San Diego, August 1, 2017 — ViaCyte, Inc., a privately - held, leading regenerative medicine company, announced today that the first patients have been implanted with the PEC - Direct ™ product candidate, a novel islet cell replacement therapy in development as a functional cure for patients with type 1 diabetes who are at high risk for acute life - threatening complications.

This group has identified IL - 7 as a fundamental mediator of T cell expansion post islet transplantation in patients with type 1 diabetes.

Neuroendocrine pancreas cells (such as islet cells) make several hormones, including insulin and glucagon, that help control sugar levels in the blood.

The anti-inflammatory effect of GABA may be vital in the pancreatic islets since as long as GABA is present, toxic white blood cells can be inhibited, thus increasing the survival of the insulin - secreting beta cells.

As of 2015, this program has supported 341 studies that address multiple areas of diabetes research relating to islet cells.

The paper provides a critical resource for ongoing research into islet biology and diabetes pathogenesis, with further insight certain as more islet cells from more individuals are analyzed.

When the beta cells decrease in number and disappear from the islets as happens in Type 1 diabetes, then GABA consequently is also decreased and, thereby, the GABA protective shielding of the beta cells.

If someone has an immune response to wheat, but it does not result in celiac, they will manifest that in other ways, such as becoming Type 1 diabetic because the immune response has killed the islet cells, or their thyroid becomes inactive or cancerous... or their spleen swells up, or they manifest arthritis or rheumatic illness of some kind....

Alpha Lipoic Acid Monograph Alternative Medicine Review 1998 (Aug); 3 (4): 308 — 311 ~ FULL TEXT Acting as a potent antioxidant, DHLA was found to protect rat pancreatic islet cells from destruction by reactive oxygen species.

The Risk of Islet Cell and Insulin Autoantibodies and Their Predictive Strength as Markers of Type - 1 Diabetes in a Cross-Section of Nigerian Population