Sentences with phrase «islet cells from»

Alpha Lipoic Acid Monograph Alternative Medicine Review 1998 (Aug); 3 (4): 308 — 311 ~ FULL TEXT Acting as a potent antioxidant, DHLA was found to protect rat pancreatic islet cells from destruction by reactive oxygen species.

The paper provides a critical resource for ongoing research into islet biology and diabetes pathogenesis, with further insight certain as more islet cells from more individuals are analyzed.

The approach is especially promising because stem cells are a renewable source of beta cells, meaning patients can generate many more islet cells from one pancreas than could be gathered by extracting only the mature islet cells.

San Diego, CA (December 9, 2008)-- Novocell, Inc., a stem cell engineering company, today announced a collaboration with renowned stem cell researcher Dr. Shinya Yamanaka of Kyoto University, Japan, to allow Novocell to explore the creation of human islet cells from induced pluripotent stem (iPS) cells.

We got islet cells from the pancreases of healthy dogs, encapsulated them, and transferred them to diabetic dogs, who became insulin independent.

They also developed a unique cell - sorting technique to isolate islet cells from other cells in the pancreas.

Not exact matches

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

«Islet cells are very precious because we get so few from each donor.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

Pancreatic neuroendocrine tumors, often referred to as «islet cell tumors» are a type of cancer that arises from hormone - releasing cells in the pancreas.

Investigators found that autophagy plays a role in clearing IAPP from pancreatic beta cells using three experimental models: pancreatic beta cells, isolated pancreatic islets from mice that express the human form of IAPP, and human islets.

At the annual meeting of the American Diabetes Society in Washington, D.C., researchers from the medical schools of Keio and Osaka universities reported that they had substituted a tumor - derived islet for Faustman's spleen cells.

Faustman got her idea by chance while transplanting islets, the pancreatic bodies that contain beta cells, from normal mice into others that had lost theirs to type 1, or juvenile, diabetes.

How did you get from islet cells to embryonic ones?

According to a joint statement, Geron holds exclusive rights to develop therapeutic and diagnostic products from neural, cardiomyocyte, and pancreatic islet cells.

Perhaps of greater importance than a putative interindividual transmission, the prion phenomenon may have a key role in spreading the pathology from cell to cell or from islet to islet during the progression of the disease.

In addition, the molecular beacons technique http://www.lependart.com could have broad applications across regenerative medicine, because it could be used with other types of cells produced from stem cell cultures, such as brain cells or insulin - producing islet cells.

In pre-clinical experiments, hESC - derived cardiomyocytes engraft in damaged myocardium and appear to behave like native cells; hESC - derived islet cells engraft, produce the hormones of the endocrine pancreas, and appear to do so under homeostatic control; etc. \ n \ nThere is no evidence of teratomas from differentiated hESC - derived cells and minimal, if any, immune rejection.

Review of «Tumor - Free Transplantation of Patient - Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration» from Stem Cells Translational Medicine by Stuart P. Atkinson

ASCs isolated from the stromal vascular fraction of fat have advantages over other mesenchymal stem cell sources; they are easy to isolate and expand and aid in the repair of damaged tissues [7], including islet graft survival and revascularization [8].

In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.

San Diego, January 8, 2015 — ViaCyte, Inc., a privately - held regenerative medicine company with the first stem cell - derived islet replacement therapy for the treatment of diabetes in clinical trials, has received a No Objection Letter from Health Canada providing clearance to proceed with sites in Canada for the Company's Phase 1/2 clinical trial of its VC - 01TM product candidate.

On the other hand, a Brs3 agonist promoted insulin secretion in both rodent insulinoma cell lines and in islets isolated from wild - type but not Brs3 mutants [53].

But the application describes ViaCyte's technology, which grows pancreatic «islet» cells from human embryonic stem cells.

«You can totally protect those mice from mortality, which is really extraordinary,» says Dr. Lipes, an Investigator in Joslin's Section on Islet Cell & Regenerative Biology and an Assistant Professor at Harvard Medical School.

In the past three years, Novocell has published three of the leading publications outlining the biological path for creating functional islets from stem cells.

When implanted, PEC - 01 cells are expected to differentiate into pancreatic islet cells that produce insulin and other hormones that regulate blood sugar, while the Encaptra device is designed to protect the cells from immune destruction.

To overcome this limitation, a team led by JAX Assistant Professor Michael Stitzel, Ph.D., isolated single cells from the pancreatic islets of both non-diabetic and type 2 diabetic subjects to obtain transcriptomes for each cell.

Finally, analyses of transcriptomic data revealed increased FGF2 expression in ductal, endothelial, and stellate cells in pancreas from T2D patients, whereas FGFR1, SOX, 9 and HES1 expression increased in islets from T2D patients.

To create a lasting source of insulin - producing beta cells for transplant, we are developing new methods to promote differentiation from pancreatic stem cells into healthy islets.

«The efficient production of endoderm represents the first critical step in the creation of a renewable islet source derived from hES cells that is targeted at restoring normal glucose regulation in diabetic patients.»

When the beta cells decrease in number and disappear from the islets as happens in Type 1 diabetes, then GABA consequently is also decreased and, thereby, the GABA protective shielding of the beta cells.

We observed that this pathogenic process was active in human islet cells obtained from donors with type 2 diabetes... [7]

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

Podgers died from islet cell neuroendocrine cancer, barely one year after his retirement.