Sentences with phrase «islet cells of the pancreas»

«Novocell is a leader in differentiation of stem cells to create functional islet cells of the pancreas, and this broad patent significantly enhances our proprietary position and further secures our investment in the development of a diabetes cell therapy and potentially other endoderm - derived cell products,» said Edward Baetge, Ph.D., Senior Vice President and Chief Scientific Officer of Novocell.

Diabetes results when either the islets cells of the pancreas lack the ability to secrete adequate levels of insulin in response to absorbed dietary glucose, or the cellular insulin receptors are unresponsive to insulin.

Chemo - receptors in the blood vessels detect the spike in blood glucose, and then signal the islet cells of the pancreas to secrete a hormone called insulin.

Not exact matches

Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin - producing (islet, or islets of Langerhans) cells in the pancreas.

Pancreatic neuroendocrine tumors, often referred to as «islet cell tumors» are a type of cancer that arises from hormone - releasing cells in the pancreas.

«Studying human islet cells has been a major challenge in the field of diabetes research for decades because the pancreas essentially digests itself shortly after a person's death,» said professor of developmental biology Seung Kim, MD, PhD.

In type 1 diabetes, the immune system attacks and destroys insulin - producing cells in the islets of the pancreas.

When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.

We got islet cells from the pancreases of healthy dogs, encapsulated them, and transferred them to diabetic dogs, who became insulin independent.

GREEN GLOB - LINS Spurred by a dose of misfolded proteins, a 20 - week - old mouse developed clumps of deformed proteins (green) in a cluster of cells called an islet (red) in its pancreas.

Accounting for about 1 percent of all pancreatic cancers, pNET is a cancer of the endocrine cells, known clinically as the islets of Langerhans, which exist in small clusters throughout the pancreas.

Image of non-diabetic healthy human islet cells that reside in pancreas.

* In type 1 diabetes, the insulin - producing cells in the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cells).

In the case of whole pancreas transplantation, major surgery is required; and in beta cell islet transplantation, the body's immune system can still attack the transplanted cells and kill off a large proportion of them (80 % in some cases).

Moreover, all of the donated pancreases displayed active insulin - producing beta cells, with some of the cells scattered individually and others clumped with different kinds of hormone - producing cells in the normal pancreatic structures called islets.

In pre-clinical experiments, hESC - derived cardiomyocytes engraft in damaged myocardium and appear to behave like native cells; hESC - derived islet cells engraft, produce the hormones of the endocrine pancreas, and appear to do so under homeostatic control; etc. \ n \ nThere is no evidence of teratomas from differentiated hESC - derived cells and minimal, if any, immune rejection.

Marciniak A, Cohrs CM, Tsata V, Chouinard JA, Selck C, Stertmann J, Reichelt S, Rose T, Ehehalt F, Weitz J, Solimena M, Slak Rupnik M, Speier S Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology.

The treatment could provide what the company calls a virtual cure for Type 1 diabetes, which is caused by a lack of insulin - producing «islet» cells in the pancreas.

For example, we're one of a handful of hospitals in the country to offer total pancreatectomy with islet cell autotransplantation (autologous islet cell transplantation), a procedure aimed at preventing diabetes or reducing its effects after removal of the pancreas due to pancreatitis.

The markers highlighted the striking diversity of beta cell aging, and functional decline, both within and between islets in both mouse and human pancreases.

The approach is especially promising because stem cells are a renewable source of beta cells, meaning patients can generate many more islet cells from one pancreas than could be gathered by extracting only the mature islet cells.

Finally, analyses of transcriptomic data revealed increased FGF2 expression in ductal, endothelial, and stellate cells in pancreas from T2D patients, whereas FGFR1, SOX, 9 and HES1 expression increased in islets from T2D patients.

Research is already underway at City of Hope to unlock the immune system's role in diabetes, including T cell modulation and stem cell - based therapies that may reverse the autoimmune attack on islet cells in the pancreas, which is the cause of T1D.

Insulin is a hormone made in the beta cells in the islets of Langerhansin the pancreas.

A novel investigative study published in the Nov 2014 issue of the Journal of Endocrinology looked at the effects of curcumin on insulin - producing cells within the pancreas called Beta cells (or B - cells) and Islet cells, in relation to imbalanced blood sugar.

The hormone insulin is secreted by beta - cells, and glucagon is secreted by α - cells that are clumped together in little islands (islets of Langerhans) in the pancreas.

Patients with Type - 1 diabetes don't have enough healthy islets of Langerhans cells — hormone - secreting cells of the pancreas.

It is critical to monitor insulin needs very closely if an attempt is made to correct high blood sugar using insulin in a dog with acute pancreatitis, in order to avoid the risk of shock due to an over dosage of insulin when the islet cell function returns and the pancreas begins to make insulin normally.

A number of mechanisms are responsible for decreased insulin secretion or resistance, but most involve destroying islet cells, the cells of the pancreas that produce insulin.

An insulinoma is a tumor of the insulin - secreting cells of the pancreas (i.e., the pancreatic islet cells).

The endocrine system includes the adrenal glands, thyroid gland, parathyroid gland, pituitary gland and specialized cells in the pancreas called the Islets of Langerhans.

Diabetes is caused by degeneration of insulin - producing cells in the pancreas (in the Islets of Langerhaans to be precise).

This is in contrast to diabetes mellitus type 1, in which there is an absolute insulin deficiency due to destruction of islet cells in the pancreas.