Sentences with phrase «isoforms bound»

Not exact matches

Adding to the documented complexity of IL - 15 — related activity, multiple isoforms and splice variants of IL - 15Rα exist as both membrane - bound and soluble forms that can either inhibit or potentiate IL - 15 biological activity (29 — 33).

The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL - 6 corepressor.

Two isoforms of the cold - inducible mRNA - binding protein RBM3 localize to dendrites and promote translation.

Using surface plasmon resonance experiments, an in vitro method for determining molecular binding partners, the researchers found that both ApoE4 and ApoE3 — an ApoE isoform associated with a lower risk of AD compared to ApoE4 — bound the SIRT1 promoter.

We replaced exon 3, which encodes a part of the RNA binding domain and is present in all Boule isoforms (Figure 3C), with a lacZ - neo vector through homologous recombination in embryonic stem cells.

Conversely, down - regulation of PKAc1 or stabilisation of a dominant - negative PKAr isoform that does not bind cAMP triggers premature parasite egress from infected cells followed by serial invasion attempts leading to host cell lysis.

Of the three isoforms of ApoE, E4 is unique in its inability to bind tau.

The E3 isoform has been proven to bind to tau (with the same suspected for E2), thus preventing or minimizing its phosphorylation.

Yong Ming Li and Dennis W. Dickson, «Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer's disease,» Neuroscience Letters (1997), Volume 226, Issue 3, 155 - 158; doi: 10.1016 / S0304 - 3940 (97) 00266 - 8.